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AB109961

重组人 SULT1A2 蛋白 (His tag N-Terminus)

Recombinant Human SULT1A2 protein (His tag N-Terminus)

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Recombinant Human SULT1A2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 295 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

查看别名

STP2, SULT1A2, Sulfotransferase 1A2, ST1A2, Aryl sulfotransferase 2, Phenol sulfotransferase 2, Phenol-sulfating phenol sulfotransferase 2, P-PST 2

1 Images
SDS-PAGE - Recombinant Human SULT1A2 protein (AB109961)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SULT1A2 protein (AB109961)

15% SDS-PAGE analysis of 3μg ab109961.

关键信息

纯度

>95% SDS-PAGE

ab109961 was purified using conventional chromatography techniques.

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

Mass Spec, SDS-PAGE

applications

生物活性

No

访问

P50226

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.058% Sodium chloride, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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搭配使用产品

Primary Antibodies

AB32078

Anti-Src (phospho Y529) antibody [Y232]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Src (phospho Y529) antibody [Y232] (AB32078)

  • 5
  • 2
Primary Antibodies

AB40660

Anti-SRC Family (phospho Y418) antibody [EP503Y]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-SRC Family (phospho Y418) antibody [EP503Y] (AB40660)

  • 4
  • 2
Primary Antibodies

AB32517

Anti-MEK2 antibody [Y78]

20ul selling size|KO Validated|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-MEK2 antibody [Y78] (AB32517)

  • 4
  • 3
Proteins & Peptides

AB79635

Recombinant human Src protein

Functional Studies - Recombinant human Src protein (AB79635)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMELIQDISRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL","proteinLength":"Full Length","predictedMolecularWeight":"36.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":295,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P50226","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SULT1A2 also known as Sulfotransferase Family 1A Member 2 is an enzyme involved in the sulfonation pathway. This enzyme has a molecular weight of approximately 34 kDa and is expressed mainly in the liver as well as other tissues like the intestines and lungs. Mechanically SULT1A2 functions by transferring sulfate groups to various substrates including hormones drugs and xenobiotic compounds. This enzymatic activity plays an important role in increasing the solubility of these molecules facilitating their excretion from the body.
Biological function summary

The sulfonation activity of SULT1A2 contributes to the regulation and metabolism of hormones and drugs. It is not part of a larger complex but works independently to modulate hormone activity and detoxify xenobiotics. This enzyme's ability to modify the biochemical properties of its substrates is essential in cellular regulation and homeostasis impacting physiological processes in humans.

Pathways

The activity of SULT1A2 is involved in the metabolism and detoxification pathways. It closely interacts with other phase II detoxification enzymes such as those in the UDP-glucuronosyltransferase family. Through these pathways SULT1A2 helps transform hydrophobic compounds into more hydrophilic forms aiding in their elimination from the organism. The enzyme's role in hormone homeostasis connects it to pathways involving hormone regulation and action.

SULT1A2 has links to certain cancers and drug metabolism disorders. In cancers altered expression levels of SULT1A2 may affect the balance of hormones potentially contributing to oncogenesis. It has also been noted in disorders of drug metabolism where malfunction of SULT1A2 can impact the efficacy and toxicity of administered medications. The enzyme interacts with cytochrome P450 family proteins which play roles in the metabolic pathways of both drugs and endogenous compounds.
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常规信息

功能

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

序列相似性

Belongs to the sulfotransferase 1 family.

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产品实验方案

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靶点信息

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
See full target information SULT1A2
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