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AB256160

重组人STIP1/STI1蛋白(His tag)

Recombinant human STIP1/STI1 protein (His tag)

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Recombinant human STIP1/STI1 protein (His tag) is a Human Full Length protein, in the 1 to 543 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, WB, FuncS.

查看别名

Stress-induced-phosphoprotein 1, STI1, Hsc70/Hsp90-organizing protein, Renal carcinoma antigen NY-REN-11, Transformation-sensitive protein IEF SSP 3521, Hop, STIP1

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SDS-PAGE - Recombinant human STIP1/STI1 protein (His tag) (AB256160)
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Supplier Data

SDS-PAGE - Recombinant human STIP1/STI1 protein (His tag) (AB256160)

SDS-PAGE - Recombinant Human STIP1/STI1 protein (His tag) (ab256160)

关键信息

纯度

>90%

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

FuncS, WB, SDS-PAGE

applications

生物活性

No

访问

P31948

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.2 Constituents: 10% Glycerol (glycerin, glycerine), 0.596% HEPES, 0.292% Sodium chloride, 0.015% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGHHHHHHMEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLIAIR","proteinLength":"Full Length","predictedMolecularWeight":"63 kDa","actualMolecularWeight":null,"aminoAcidEnd":543,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P31948","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

STIP1 also known as STI1 is a stress-induced phosphoprotein that assists in the folding and stabilization of other proteins. The protein has a mass of approximately 63 kDa. It acts as a co-chaperone and interacts with key chaperones like HSP70 and HSP90 facilitating the transfer of client proteins between them. STIP1 is expressed in various tissues with significant presence in the nervous system and reproductive organs. It contributes to the protein homeostasis by modulating chaperone activity and protecting cells during stress conditions like high temperatures or oxidative stress.
Biological function summary

The stress-induced phosphoprotein STIP1 functions within cytoplasm and is pivotal for cellular integrity. It forms a complex with HSP70 and HSP90 that regulates the folding and activation of a range of client proteins including steroid hormone receptors and kinases. This modulation influences protein activity stability and degradation. STIP1 impacts signal transduction pathways cellular growth and stress responses by influencing how effectively client proteins perform their biological roles within cells.

Pathways

The protein STIP1 plays a significant part in the steroid hormone signaling pathway and the protein folding network. It helps facilitate the proper folding and function of steroid hormone receptors through its interaction with major chaperone proteins HSP70 and HSP90. Both these pathways are important for cell survival and proper cell regulation. By helping with the maturation and activation of client proteins STIP1 ensures that cellular responses to various internal and external signals proceed efficiently.

The involvement of STIP1 emerges most clearly in neurodegenerative conditions like Alzheimer's disease and cancer. In Alzheimer's disease STIP1 interacts with prion proteins which influence amyloid-beta aggregation and may impact disease progression. In cancer the protein assists in stabilizing client proteins essential for tumor progression such as steroid hormone receptors and protein kinases. Disruption in STIP1 function can lead to impaired cellular stress responses and may contribute to disease pathogenesis.
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特殊说明

形式

Liquid

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常规信息

功能

Acts as a co-chaperone for HSP90AA1 (PubMed : 27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Acts as a co-chaperone for HSP90AA1 (PubMed : 27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).
See full target information STIP1
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搭配使用产品

Reagents, Controls & Accessories

AB325997

Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color) (AB325997)

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Primary Antibodies

AB126724

Anti-STIP1/STI1 antibody [EPR6605]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STIP1/STI1 antibody [EPR6605] (AB126724)

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Proteins & Peptides

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Recombinant Human ULBP2 protein

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Proteins & Peptides

AB219428

Recombinant Human SLAMF6 protein (His tag C-Terminus)

SDS-PAGE - Recombinant Human SLAMF6 protein (His tag C-Terminus) (AB219428)

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