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AB177658

重组人 STEAP4 蛋白 (denatured) (His-DDDDK tag N-Terminus)

Recombinant Human STEAP4 protein (denatured) (His-DDDDK tag N-Terminus)

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Recombinant Human STEAP4 protein (denatured) (His-DDDDK tag N-Terminus) is a Human Fragment protein, in the 1 to 152 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

查看别名

STAMP2, TNFAIP9, STEAP4, Metalloreductase STEAP4, Six-transmembrane epithelial antigen of prostate 4, SixTransMembrane protein of prostate 2

1 Images
SDS-PAGE - Recombinant Human STEAP4 protein (denatured) (His-DDDDK tag N-Terminus) (AB177658)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human STEAP4 protein (denatured) (His-DDDDK tag N-Terminus) (AB177658)

SDS-PAGE of ab177658 (3µg) under reducing condition and visualized by coomassie blue stain.

关键信息

纯度

>90% SDS-PAGE

表达系统

Escherichia coli

标签

His-DDDDK tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q687X5

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSMEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSGAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDASRQ","proteinLength":"Fragment","predictedMolecularWeight":"20.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":152,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q687X5","tags":[{"tag":"His-DDDDK","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

STEAP4 also known as STEAP4 metalloreductase or TIARP is a membrane-associated protein with a molecular mass of approximately 51 kDa. It mainly functions as a metalloreductase playing a role in the reduction of metal ions particularly iron and copper within cells. You find its expression in various tissues with higher levels in the adipose tissue liver and prostate. This protein is integral to cellular processes that require metal ion homeostasis influencing several pathways through its enzymatic activity on metal reduction.
Biological function summary

The function of STEAP4 extends beyond mere metal ion reduction. It contributes to cellular metabolism and inflammatory response regulation. Researchers have noted its involvement in the modulation of reactive oxygen species (ROS) which are important for detoxification and signaling. This protein does not function in isolation but may work in concert with other proteins in complexes related to the cell membrane and energy metabolism.

Pathways

STEAP4 participates in critical metabolic and inflammatory pathways. In particular it plays a role in the JNK and NF-kB signaling pathways which impact cellular stress responses and inflammation. Interactions with additional regulatory proteins such as TNF-alpha and IL-6 further integrate STEAP4 into these pathways linking its functions with larger cellular processes that respond to external stimuli and stress factors.

STEAP4 has important connections to metabolic and inflammatory conditions. Research shows its involvement in obesity-related inflammation and insulin resistance linking it with metabolic syndrome conditions. You also find associations between STEAP4 expression and type 2 diabetes as its dysfunction may impact glucose and lipid metabolism. This protein's interactions with TNF-alpha and IL-6 also suggest a strong link to chronic inflammatory states which can exacerbate metabolic disorders.
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特殊说明

形式

Liquid

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常规信息

功能

Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed : 30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed : 18381574, PubMed : 18430367). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed : 19660107). Inhibits anchorage-independent cell proliferation (PubMed : 19787193).

序列相似性

Belongs to the STEAP family.

亚细胞定位

Early endosome membrane

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产品实验方案

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靶点信息

Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed : 30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed : 18381574, PubMed : 18430367). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed : 19660107). Inhibits anchorage-independent cell proliferation (PubMed : 19787193).
See full target information STEAP4
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