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AB166097

重组人 STEAP2 蛋白 (GST tag N-Terminus)

Recombinant Human STEAP2 protein (GST tag N-Terminus)

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Recombinant Human STEAP2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 490 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

PCANAP1, STAMP1, UNQ6507/PRO23203, STEAP2, Metalloreductase STEAP2, Prostate cancer-associated protein 1, Protein up-regulated in metastatic prostate cancer, Six-transmembrane epithelial antigen of prostate 2, SixTransMembrane protein of prostate 1, PUMPCn

1 Images
SDS-PAGE - Recombinant Human STEAP2 protein (GST tag N-Terminus) (AB166097)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human STEAP2 protein (GST tag N-Terminus) (AB166097)

ab166097 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, ELISA

applications

生物活性

No

访问

Q8NFT2

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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搭配使用产品

Reagents, Controls & Accessories

AB116028

Prestained Protein Ladder - Broad molecular weight (10 - 245 kDa)

SDS-PAGE - Prestained Protein Ladder - Broad molecular weight (10 - 245 kDa) (AB116028)

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  • 3
Reagents, Controls & Accessories

AB110413

Total OXPHOS Rodent WB Antibody Cocktail

Western blot - Total OXPHOS Rodent WB Antibody Cocktail (AB110413)

  • 5
  • 18
Assay Kits

AB65336

Triglyceride Assay Kit - Quantification

Biochemical assay - Triglyceride Assay Kit - Quantification (AB65336)

  • 4
  • 5
Proteins & Peptides

AB314537

Recombinant Macaca fascicularis Claudin18.2 protein - Active

Bioactive

Functional Studies - Recombinant Macaca fascicularis Claudin18.2 protein - Active (AB314537)

  • 0
  • 0
Primary Antibodies

AB134161

Anti-CD276 antibody [EPNCIR122]

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-CD276 antibody [EPNCIR122] (AB134161)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFEEEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIPHVSPERVTVM","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":490,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8NFT2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
纯化工艺
Proprietary technique
运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

STEAP2 also known as six transmembrane epithelial antigen of the prostate 2 is a metalloreductase with a mass of about 56 kDa. It facilitates the reduction of metal ions in a process dependent on FAD and NADPH. Expressed mainly in the prostate STEAP2 also appears in other tissues at lower levels. This protein exhibits a tendency to localize to cellular membranes and endocytic vesicles aiding in the uptake and processing of metal ions like iron and copper which are important for cellular activities.
Biological function summary

STEAP2 plays a role in ion homeostasis and cellular proliferation. It acts as part of a complex involving other STEAP family members contributing to the reduction of metal ions essential for various cellular processes. Its ability to mediate electron transport is important for maintaining the balance of redox reactions critical for normal cellular functions. The involvement in cellular proliferation ties STEAP2 to tissue development and repair mechanisms.

Pathways

STEAP2 interacts within metal ion transport and homeostasis pathways influencing processes like oxidative stress responses. It associates with proteins such as ferritin important for iron storage and metallothioneins linked to metal detoxification. These interactions are essential for regulating intracellular metal ion concentrations thereby impacting cellular health and function. It also relates to cellular growth pathways connecting it to certain growth factor signals.

Abnormal STEAP2 expression links to prostate cancer and other proliferative disorders. Its overexpression in prostate cancer cells correlates with increased tumor aggressiveness and progression. STEAP2 interacts with other oncogenic proteins such as PSA (prostate-specific antigen) which are critical in the diagnosis and progression monitoring of prostate cancer. Additionally alterations in STEAP2 function may affect systemic metal ion homeostasis potentially contributing to disorders like hemochromatosis although this link is less well-defined in clinical settings.
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常规信息

功能

Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity).

序列相似性

Belongs to the STEAP family.

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产品实验方案

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靶点信息

Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity).
See full target information STEAP2
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