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AB162041

重组人 STEAP1 蛋白 (GST tag N-Terminus)

Recombinant Human STEAP1 protein (GST tag N-Terminus)

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Recombinant Human STEAP1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 339 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

PRSS24, STEAP, STEAP1, STEAP1 protein, Six-transmembrane epithelial antigen of prostate 1

1 Images
SDS-PAGE - Recombinant Human STEAP1 protein (GST tag N-Terminus) (AB162041)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human STEAP1 protein (GST tag N-Terminus) (AB162041)

ab162041 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, ELISA

applications

生物活性

No

访问

Q9UHE8

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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搭配使用产品

Reagents, Controls & Accessories

AB234592

Prestained Protein Ladder - Extra broad molecular weight (6.5 - 270 kDa)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (6.5 - 270 kDa) (AB234592)

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Proteins & Peptides

AB277009

Recombinant Mouse OSTM1 protein (His tag)

SDS-PAGE - Recombinant Mouse OSTM1 protein (His tag) (AB277009)

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Primary Antibodies

AB207914

Anti-STEAP1 antibody [J2D2] - N-terminal

Western blot - Anti-STEAP1 antibody [J2D2] - N-terminal (AB207914)

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Proteins & Peptides

AB162126

Recombinant Human MMADHC protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human MMADHC protein (GST tag N-Terminus) (AB162126)

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Proteins & Peptides

AB276605

Recombinant Human SEZ6L2 protein (His tag)

SDS-PAGE - Recombinant Human SEZ6L2 protein (His tag) (AB276605)

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  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"MESRKDITNQEELWKMKPRRNLEEDDYLHKDTGETSMLKRPVLLHLHQTAHADEFDCPSELQHTQELFPQWHLPIKIAAIIASLTFLYTLLREVIHPLATSHQQYFYKIPILVINKVLPMVSITLLALVYLPGVIAAIVQLHNGTKYKKFPHWLDKWMLTRKQFGLLSFFFAVLHAIYSLSYPMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNKWIDIKQFVWYTPPTFMIAVFLPIVVLIFKSILFLPCLRKKILKIRHGWEDVTKINKTEICSQL","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":339,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9UHE8","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
纯化工艺
Proprietary technique
运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

STEAP1 also known as Six Transmembrane Epithelial Antigen of the Prostate 1 is a plasma membrane protein with a molecular weight around 50 kDa. This protein is expressed primarily in prostate tissues but also in a variety of other epithelial tissues. It plays a mechanical role as a metalloreductase facilitating the reduction of metal ions such as iron and copper across the cell membrane. STEAP1 features a characteristic six transmembrane domain which is important for its activity and localization.
Biological function summary

STEAP1 impacts cellular processes connected to metal ion homeostasis and proliferation. By performing as a metalloreductase it modulates the redox state and availability of metal ions within cells. STEAP1 functions as part of a larger complex interacting with other transmembrane proteins in the regulation of ion transport and reduction reactions. These roles are significant in maintaining cellular metabolism and oxidative balance.

Pathways

STEAP1 is actively involved in pathways related to iron and copper metabolism. It links to the iron uptake and transport pathways ensuring proper cellular iron levels are maintained. STEAP1 also shares functional relationships with proteins such as ferritin which stores iron and transferrin which transports iron in the bloodstream. STEAP1 therefore plays an important part in connecting cellular metabolism to systemic metal homeostasis.

STEAP1 has notable associations with prostate cancer and Ewing's sarcoma. Elevated expression of STEAP1 often correlates with the progression of prostate cancer hinting at a potential role in tumor growth and survival. In Ewing's sarcoma STEAP1 engages in molecular mechanisms related to the disease's pathology. Interaction with proteins such as PCA3 a prostate cancer antigen underlines its involvement in carcinogenic processes and highlights its potential as a therapeutic target in oncology.
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常规信息

功能

Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4.

序列相似性

Belongs to the STEAP family.

亚细胞定位

Endosome membrane

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产品实验方案

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靶点信息

Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4.
See full target information STEAP1
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