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AB132279

Recombinant Human STAM2 protein

Recombinant Human STAM2 protein

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Recombinant Human STAM2 protein is a Human Full Length protein, in the 1 to 525 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

查看别名

HBP, STAM2, Signal transducing adapter molecule 2, STAM-2, Hrs-binding protein

1 Images
SDS-PAGE - Recombinant Human STAM2 protein (AB132279)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human STAM2 protein (AB132279)

12.5% SDS-PAGE analysis of ab132279 stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

Tag free

应用

SDS-PAGE, ELISA, WB

applications

生物活性

No

访问

O75886

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALELYNKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSHGGNYMGQSIHQVTVAQSYSLGPDQIGPLRSLPPNVNSSVTAQPAQTSYLSTGQDTVSNPTYMNQNSNLQSATGTTAYTQQMGMSVDMSSYQNTTSNLPQLAGFPVTVPAHPVAQQHTNYHQQPLL","proteinLength":"Full Length","predictedMolecularWeight":"83.49 kDa","actualMolecularWeight":null,"aminoAcidEnd":525,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O75886","tags":[]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

STAM2 also known as STAM2b acts as a signal transducing adaptor molecule. STAM2 has a mass of approximately 69 kDa and is located in the cytoplasm. It expresses widely with notable presence in the brain and immune cells. Mechanically STAM2 contains multiple functional domains including a VHS domain and a UIM domain which participate in binding ubiquitinated proteins. These features allow STAM2 to mediate interactions in cellular processes involving intracellular signaling.
Biological function summary

STAM2 plays a role in the sorting and trafficking of proteins within the cell. It forms part of the ESCRT-0 complex which is important for sorting ubiquitinated cargo into the multivesicular body (MVB) pathway. This pathway is important for the degradation of membrane proteins in lysosomes and regulating various signaling pathways including endocytosis. The involvement of STAM2 in these processes makes it essential for maintaining cellular homeostasis and regulating signal transduction.

Pathways

STAM2 is involved in both the endocytic and lysosomal degradation pathways. Within these pathways STAM2 interacts with Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) another component of the ESCRT-0 complex to regulate the sorting of endocytic cargo. This interaction is part of a larger network connecting the endocytic pathway with other cellular processes such as ubiquitin-dependent protein degradation. STAM2's functions align it with pathways necessary for proper protein turnover and cellular signaling adjustments.

STAM2's dysregulation has a noted connection to neurodegenerative diseases such as Alzheimer's disease. Changes in protein trafficking and degradation which involve STAM2 function correlate with the buildup of abnormal protein aggregates in neurons. Additionally STAM2 has been implicated in certain cancers where its interaction with proteins such as EGFR (epidermal growth factor receptor) may influence tumor growth and metastasis. Understanding how STAM2 contributes to these conditions could offer insight into potential therapeutic targets.
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特殊说明

形式

Liquid

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常规信息

功能

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

序列相似性

Belongs to the STAM family.

翻译后修饰

Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.

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产品实验方案

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靶点信息

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
See full target information STAM2
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