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AB180301

重组人STAC蛋白(denatured)

Recombinant Human STAC protein (denatured)

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Recombinant Human STAC protein (denatured) is a Human Full Length protein, in the 1 to 402 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

查看别名

STAC1, STAC, SH3 and cysteine-rich domain-containing protein, Src homology 3 and cysteine-rich domain-containing protein

1 Images
SDS-PAGE - Recombinant Human STAC protein (denatured) (AB180301)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human STAC protein (denatured) (AB180301)

15% SDS-PAGE analysis of ab180301 (3μg).

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q99469

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNFFQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEANGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI","proteinLength":"Full Length","predictedMolecularWeight":"46.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":402,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q99469","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

STAC also known as SH3 and cysteine-rich domain 3 is a protein with a known molecular mass of approximately 38 kilodaltons. Structurally STAC contains a domain known as the SH3 domain which aids in protein-protein interactions. STAC expresses widely in various tissues including the brain heart and skeletal muscle. It interacts with other proteins through its cysteine-rich domain playing roles in cellular signaling.
Biological function summary

Proteins with SH3 domains like STAC contribute to intracellular signaling pathways. STAC interacts within complexes that modulate ion channel activities which is important for cellular excitability. It holds an essential role in synaptic transmission and muscle contraction functions. The presence of STAC in the membrane and cytosolic compartments suggests its involvement in dynamic cellular processes.

Pathways

STAC participates in both the calcium signaling pathway and the excitation-contraction coupling pathway. In calcium signaling it regulates calcium channels which are critical for maintaining cellular calcium homeostasis. Additionally STAC is involved with the excitation signal pathway by interacting with proteins such as RyR1 (Ryanodine Receptor 1) that facilitate calcium release in muscle contraction. This integration affects the overall physiological response during muscle excitation.

STAC shows an association with cardiac arrhythmias and muscular dystrophy. Mutations or altered expression in STAC can impact calcium homeostasis and muscle function contributing to these conditions. Additionally STAC links to the CACNA1S protein in muscular disorders associated with calcium channel dysfunction which further highlights its role in the pathophysiology of these diseases.
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特殊说明

形式

Liquid

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常规信息

功能

Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.

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产品实验方案

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靶点信息

Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.
See full target information STAC
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