JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB86438

重组人SPG21/Maspardin蛋白

Recombinant Human SPG21/Maspardin protein

Be the first to review this product! Submit a review

|

(1 Publication)

Recombinant Human SPG21/Maspardin protein is a Human Full Length protein, in the 1 to 308 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

查看别名

ACP33, BM-019, GL010, SPG21, Maspardin, Acid cluster protein 33, Spastic paraplegia 21 autosomal recessive Mast syndrome protein, Spastic paraplegia 21 protein

1 Images
Western blot - Recombinant Human SPG21/Maspardin protein (AB86438)
  • WB

Unknown

Western blot - Recombinant Human SPG21/Maspardin protein (AB86438)

15% SDS-PAGE showing ab86438 at approximately 37.1kDa (3μg).

All lanes:

Western blot - Anti-TAGLN/Transgelin antibody (<a href='/products/primary-antibodies/tagln-transgelin-antibody-ab14106'>ab14106</a>) at 1 µg/mL

Lane 1:

Western blot - Recombinant Human TAGLN/Transgelin protein (<a href='/products/proteins-peptides/recombinant-human-tagln-transgelin-protein-ab101469'>ab101469</a>) at 0.01 µg

Lane 1:

Western blot - Recombinant Human SPG21/Maspardin protein (ab86438)

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (<a href='/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-preadsorbed-ab97080'>ab97080</a>) at 1/5000 dilution

Predicted band size: 23 kDa,35 kDa

true

Exposure time: 30s

关键信息

纯度

>95% SDS-PAGE

表达系统

Escherichia coli

标签

Tag free

应用

SDS-PAGE

applications

生物活性

No

访问

Q9NZD8

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.316% Tris HCl

storage-buffer

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column

产品详情

Endotoxin level: < 1.0 EU per 1 μg of protein (determined by LAL method). This product was previously labelled as SPG21
style
left-column

序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGEIKVSPDYNWFRGTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFRQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNSFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQEEQ","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":308,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NZD8","tags":[]}]
style
left-column

性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SPG21 also known as Maspardin is a protein involved in cellular functions with a molecular mass of approximately 48 kDa. It is widely expressed in human tissues notably in the brain and peripheral blood cells. The protein localizes mainly in the cytoplasm and connects with lipid membrane structures. Its mechanical role involves interactions with proteins in the trans-Golgi network and possibly modifies the transport functions within cells.
Biological function summary

SPG21 plays a role in cellular processes such as membrane trafficking and lysosomal function. It is a part of the protein complex involved in sorting and degrading membrane-bound proteins and lipids. Through its interactions with other proteins SPG21 helps maintain cellular homeostasis and protects cells from stress-related damage. It is sometimes associated with lysosome function regulation which is fundamental to cellular waste management.

Pathways

SPG21 interacts with molecules in the lysosomal and Golgi-related pathways. It fits into these pathways by assisting in the transport and breakdown of lysosomal enzymes. These processes are essential for cellular waste processing and lipid metabolism. SPG21 takes part in pathways with proteins like CLN3 and members of the Golgi complex sustaining cellular metabolic balance and facilitating protein recycling.

SPG21 connects closely with hereditary spastic paraplegia (HSP) and neurodegenerative disorders. Mutations in the SPG21 gene lead to a form of HSP known as Mast syndrome characterized by spasticity and neural degradation. SPG21 has potential links with proteins involved in neurodegeneration like SPG7 where dysfunctions can trigger similar symptomatic progressions. Understanding SPG21's role in these diseases aids in targeting therapeutic strategies to mitigate neurological impacts.
style
left-column

特殊说明

形式

Liquid

附加说明

ab86438 is purified using conventional chromatography techniques.

style
left-column

常规信息

功能

May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

序列相似性

Belongs to the AB hydrolase superfamily.

亚细胞定位

Endosome membrane

style
left-column

产品实验方案

style
left-column

靶点信息

May play a role as a negative regulatory factor in CD4-dependent T-cell activation.
See full target information SPG21
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of nanobiotechnology 21:305 PubMed37644565

2023

P65 mediated UBR4 in exosomes derived from menstrual blood stromal cells to reduce endometrial fibrosis by regulating YAP Ubiquitination.

Applications

Unspecified application

Species

Unspecified reactive species

Jiarui Qi,Xudong Zhang,Siwen Zhang,Shanshan Wu,Yimeng Lu,Shuyu Li,Pingping Li,Jichun Tan
View all publications
style
left-column
style
left-column
style
right-column

搭配使用产品

Proteins & Peptides

AB7403

Streptavidin (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Streptavidin (HRP) (AB7403)

  • 5
  • 7
Proteins & Peptides

AB84191

Recombinant A. victoria GFP protein

Western blot - Recombinant A. victoria GFP protein (AB84191)

  • 5
  • 3
Proteins & Peptides

AB95291

Recombinant Human Profilin 2 protein

SDS-PAGE - Recombinant Human Profilin 2 protein (AB95291)

  • 0
  • 0
Proteins & Peptides

AB101208

Recombinant Human RQCD1 protein

SDS-PAGE - Recombinant Human RQCD1 protein (AB101208)

  • 0
  • 0

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com