AB169843

重组人SOX2蛋白

Name: 重组人SOX2蛋白 (ab169843)| Abcam中文官网
Brand: Abcam Limited
SKU: AB169843
Price: 4033 CNY
Availability: InStock

Recombinant human SOX2 protein

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(4 Publications)

Recombinant human SOX2 protein is a Human Full Length protein, in the 1 to 317 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, FuncS.

查看别名

Transcription factor SOX-2, SOX2

关键信息

纯度

>90% SDS-PAGE

表达系统

Escherichia coli

应用

FuncS, SDS-PAGE

applications

生物活性

Yes

生物学活性

Active

访问

P48431

不含动物源

不含载体蛋白

种属

Human

存储溶液

pH: 7.5 Constituents: EDTA, Glycerol (glycerin, glycerine), Potassium chloride, Sodium chloride, 0.24% Tris

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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产品详情

The in vitro function was tested using specific DNA binding assays. 11R proteins were reported to successfully generate induced pluripotent stem (iPS) cells from OG2 MEFs.

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序列信息

[{"sequence":"MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQSGPVPGTAINGTLPLSHMESGGGGSPGRRRRRRRRRRR","proteinLength":"Full Length","predictedMolecularWeight":"36.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":317,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P48431","tags":[]}]

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性能和储存信息

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

True

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特殊说明

形式

Liquid

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常规信息

功能

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed : 18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity).

翻译后修饰

Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.. Methylation at Lys-42 and Lys-117 is necessary for the regulation of SOX2 proteasomal degradation.. Ubiquitinated by WWP2, leading to proteasomal degradation.

亚细胞定位

Nucleus

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information SOX2

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 18:e1010887 PubMed36223427

2022

Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites.

Applications

Unspecified application

Species

Unspecified reactive species

Timothy James Russell,Erandi K De Silva,Valerie M Crowley,Kathryn Shaw-Saliba,Namita Dube,Gabrielle Josling,Charisse Flerida A Pasaje,Irene Kouskoumvekaki,Gianni Panagiotou,Jacquin C Niles,Marcelo Jacobs-Lorena,C Denise Okafor,Francisco-Javier Gamo,Manuel Llinás

Cell reports 39:110919 PubMed35675767

2022

Stub1 maintains proteostasis of master transcription factors in embryonic stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Md Mahfuz Al Mamun,Muhammad Riaz Khan,Yifu Zhu,Yuwei Zhang,Shuai Zhou,Ran Xu,Ihtisham Bukhari,Rick F Thorne,Jinming Li,Xu Dong Zhang,Guangzhi Liu,Song Chen,Mian Wu,Xiaoyuan Song

Nature communications 12:3337 PubMed34099689

2021

High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites.

Applications

Unspecified application

Species

Unspecified reactive species

Ludovica Vanzan,Hadrien Soldati,Victor Ythier,Santosh Anand,Simon M G Braun,Nicole Francis,Rabih Murr

Molecular cell 65:589-603.e9 PubMed28212747

2017

Catalytic-Independent Functions of PARP-1 Determine Sox2 Pioneer Activity at Intractable Genomic Loci.

Applications

Unspecified application

Species

Unspecified reactive species

Ziying Liu,W Lee Kraus

View all publications

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重组人SOX2蛋白

Recombinant human SOX2 protein

关键信息

纯度

表达系统

标签

应用

生物活性

生物学活性

访问

不含动物源

不含载体蛋白

种属

存储溶液