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AB153316

重组人SLC40A1蛋白

Recombinant Human SLC40A1 protein

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Recombinant Human SLC40A1 protein is a Human Full Length protein, in the 1 to 571 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

FPN, FPN1, IREG1, SLC11A3, MSTP079, SLC40A1, Ferroportin, Ferroportin-1, Iron-regulated transporter 1, Solute carrier family 40 member 1

1 Images
SDS-PAGE - Recombinant Human SLC40A1 protein (AB153316)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SLC40A1 protein (AB153316)

ab153316 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, ELISA

applications

生物活性

No

访问

Q9NP59

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":571,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9NP59","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SLC40A1 also known as ferroportin or solute carrier family 40 member 1 is a transmembrane protein which functions as an iron transporter. This protein plays a role in exporting iron from cells into the bloodstream. The molecular weight of SLC40A1 is approximately 62 kDa. It is highly expressed in cells involved in iron storage and metabolism such as enterocytes in the duodenum and macrophages which process senescent red blood cells.
Biological function summary

The function of this transporter is important for iron homeostasis in human body. SLC40A1 helps balance iron levels by moving iron across intestinal cells into the plasma. It does not function as part of a larger protein complex but its activity is controlled by hepcidin a hormone that degrades SLC40A1 and regulates iron flow into the circulation.

Pathways

SLC40A1 is essential in the iron homeostasis pathway and the hepcidin regulation pathway. These pathways ensure iron supply matches body demands. It is closely related to hepcidin due to their interactive roles in this regulatory system. Hepcidin binds to SLC40A1 leading to its internalization and degradation which decreases iron export.

Mutations in SLC40A1 can lead to diseases like hemochromatosis characterized by excessive iron accumulation and anemia as iron transport becomes inefficient. Through these conditions SLC40A1 connects to hepcidin where disruption in their interaction contributes to disease pathology. Managing SLC40A1 activity is therefore important for maintaining proper iron levels and preventing related health issues.
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特殊说明

形式

Liquid

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常规信息

功能

Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed : 15692071, PubMed : 22178646, PubMed : 22682227, PubMed : 24304836, PubMed : 29237594, PubMed : 29599243, PubMed : 30247984). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (PubMed : 22682227, PubMed : 29237594, PubMed : 32814342).

序列相似性

Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

翻译后修饰

Polyubiquitinated by RNF217; leading to proteasomal degradation (By similarity). Under conditions of high systemic iron levels, both the hormone peptide hepcidin/HAMP and holo(iron bound)-transferrin/TF induce the ubiquitination, internalization and proteasomal degradation of SLC40A1 to control iron release from cells (PubMed:22682227, PubMed:37277838).

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产品实验方案

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靶点信息

Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed : 15692071, PubMed : 22178646, PubMed : 22682227, PubMed : 24304836, PubMed : 29237594, PubMed : 29599243, PubMed : 30247984). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (PubMed : 22682227, PubMed : 29237594, PubMed : 32814342).
See full target information SLC40A1
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