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AB153267

重组人SERBP1蛋白

Recombinant Human SERBP1 protein

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Recombinant Human SERBP1 protein is a Human Full Length protein, in the 1 to 402 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

PAIRBP1, CGI-55, SERBP1, SERPINE1 mRNA-binding protein 1, PAI1 RNA-binding protein 1, Plasminogen activator inhibitor 1 RNA-binding protein, PAI-RBP1

1 Images
SDS-PAGE - Recombinant Human SERBP1 protein (AB153267)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SERBP1 protein (AB153267)

ab153267 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, ELISA

applications

生物活性

No

访问

Q8NC51

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGEGKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNYSDLDQSNVTEETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGGCGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":402,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8NC51","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SERBP1 also known as SCR3 is a protein weighing approximately 46 kDa. This protein interacts with specific mRNA sequences acting as a binding protein that influences mRNA stability and modulates the translation process. SERBP1 is widely expressed in various tissues notably in the liver and placenta where it plays a role in cellular activities related to protein synthesis.
Biological function summary

Activities performed by SERBP1 involve regulation of mRNA turnover and translation impacting critical cellular functions. SERBP1 forms part of the ribonucleoprotein complexes which bind to mRNA and stabilize it therefore influencing gene expression. Through these interactions it has a significant impact on the control of translation processes within the cell alongside other regulatory proteins.

Pathways

SERBP1 participates in mRNA surveillance and regulation pathways. This protein interacts with key translation pathways contributing to processes that ensure only properly processed mRNA is translated into proteins. SERBP1's role in these pathways may involve interactions with proteins like eIF4E which also plays a part in translation initiation thereby maintaining cellular homeostasis and efficiency in protein production.

Changes in SERBP1 expression or function can relate to cancer and liver disease. In such conditions aberrant regulation of mRNA stability may occur leading to dysregulated protein synthesis that contributes to pathogenesis. SERBP1 is connected to proteins such as c-Myc in cancer where it may play a role in the overexpression of oncogenes linking these pathway interactions to disease states.
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特殊说明

形式

Liquid

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常规信息

功能

Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed : 36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability : binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed : 11001948). Seems to play a role in PML-nuclear bodies formation (PubMed : 28695742).

序列相似性

Belongs to the SERBP1-HABP4 family.

翻译后修饰

Phosphorylation by MTOR inhibits SERBP1 and relieves ribosome hibernation.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed : 36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability : binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed : 11001948). Seems to play a role in PML-nuclear bodies formation (PubMed : 28695742).
See full target information SERBP1
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