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AB276369

重组人Sema6A蛋白(His tag)

Recombinant Human Sema6A protein (His tag)

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Recombinant Human Sema6A protein (His tag) is a Human Fragment protein, in the 1 to 649 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

查看别名

KIAA1368, SEMAQ, SEMA6A, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1, Sema VIA, SEMA6A-1

1 Images
SDS-PAGE - Recombinant Human Sema6A protein (His tag) (AB276369)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Sema6A protein (His tag) (AB276369)

SDS-PAGE analysis of ab276369

关键信息

纯度

>90% SDS-PAGE

内毒素水平

< 1 EU/µg

表达系统

HEK 293 cells

标签

His tag C-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q9H2E6

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.4 Constituents: PBS

storage-buffer

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搭配使用产品

Primary Antibodies

AB176876

Anti-DLL4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DLL4 antibody (AB176876)

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Assay Kits

AB314392

Human Sema6A ELISA Kit

Sandwich ELISA - Human Sema6A ELISA Kit (AB314392)

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Proteins & Peptides

AB137139

Recombinant Human HES7 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human HES7 protein (denatured) (His tag N-Terminus) (AB137139)

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Primary Antibodies

AB52627

Anti-Notch1 antibody [EP1238Y]

RabMAb|Recombinant|KO Validated|20ul selling size|Advanced Validation

Western blot - Anti-Notch1 antibody [EP1238Y] (AB52627)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"MRSEALLLYFTLLHFAGAGFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIMIMNGTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMARCPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFLEEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERYGKCKKTCIASRDPYCGWIKEGGACSHLSPNSRLTFEQDIERGNTDGLGDCHNSFVALNGHSSSLLPSTTTSDSTAQEGYESRGGMLDWKHLLDSPDSTDPLGAVSSHNHQDKKGVIRESYLKGHDQLVPVT","proteinLength":"Fragment","predictedMolecularWeight":"72.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":649,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9H2E6","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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性能和储存信息

形式
Lyophilized
运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Semaphorin 6A also known as Sema6A is a transmembrane protein that plays a significant role in axon guidance and cell signaling. It has a mass of approximately 95 kDa and is a member of the semaphorin protein family. Sema6A is expressed mainly in the nervous system but also found in other tissues like the heart and kidney. In neuronal cells it interacts with plexin receptors to guide axonal pathways influencing the growth cone dynamics during neural development.
Biological function summary

Sema6A plays a role in cellular navigation during neural development. It functions as a signaling cue that aids in cell positioning by influencing the structure and orientation of the cellular cytoskeleton. Although not part of a large protein complex itself Sema6A can interact with plexins to modulate other cellular pathways. The interactions help manage axonal growth and directionality essential for proper neural circuit formation.

Pathways

Sema6A significantly influences the axon guidance and neural crest cell migration pathways. In these pathways it interacts with proteins such as plexin-A4 which play key roles in transducing semaphorin signals to the cytoskeleton. By guiding axonal direction Sema6A integrates into neural development processes as well as affecting the migration of neurons and their interaction within different tissues.

Sema6A is associated with neurodevelopmental disorders and cancer metastasis. Mutations or dysregulation within Sema6A signaling can contribute to conditions such as autism spectrum disorder where it may affect neural connectivity. In cancer irregular expression of Sema6A might influence tumor progression and metastasis by interacting with plexin receptors changing cell adhesion properties and impacting cell migration.
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常规信息

功能

Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.. (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium.

序列相似性

Belongs to the semaphorin family.

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产品实验方案

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靶点信息

Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.. (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium.
See full target information SEMA6A
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