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AB105573

重组人 S100 Calcium Binding 蛋白 A13/S100A13 (His tag N-Terminus)

Recombinant Human S100 Calcium Binding Protein A13/S100A13 (His tag N-Terminus)

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Recombinant Human S100 Calcium Binding Protein A13/S100A13 (His tag N-Terminus) is a Human Full Length protein, in the 1 to 98 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

查看别名

Protein S100-A13, S100 calcium-binding protein A13, S100A13

1 Images
SDS-PAGE - Recombinant Human S100 Calcium Binding Protein A13/S100A13 (His tag N-Terminus) (AB105573)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human S100 Calcium Binding Protein A13/S100A13 (His tag N-Terminus) (AB105573)

15% SDS-PAGE analysis of ab105573 (3ug)

关键信息

纯度

>95% SDS-PAGE

ab105573 was purified using conventional chromatography.

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q99584

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.29% Sodium chloride

storage-buffer

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搭配使用产品

Proteins & Peptides

AB41752

Human EAAT2 peptide

  • 4
  • 1
Primary Antibodies

AB205248

Anti-EAAT2 antibody [EPR19798]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Frozen sections) - Anti-EAAT2 antibody [EPR19798] (AB205248)

  • 0
  • 0
Primary Antibodies

AB109252

Anti-S100 Calcium Binding Protein A13/S100A13 antibody [EPR4510]

RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-S100 Calcium Binding Protein A13/S100A13 antibody [EPR4510] (AB109252)

  • 0
  • 0
Proteins & Peptides

AB103504

Recombinant Human N myc interactor/NMI protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human N myc interactor/NMI protein (His tag N-Terminus) (AB103504)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

This product was previously labelled as S100 Calcium Binding Protein A13
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序列信息

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMAAEPLTELEESIETVVTTFFTFARQEGRKDSLSVNEFKELVTQQLPHLLKDVGSLDEKMKSLDVNQDSELKFNEYWRLIGELAKEIRKKKDLKIRKK","proteinLength":"Full Length","predictedMolecularWeight":"13.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":98,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q99584","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

S100 Calcium Binding Protein A13 also known as S100A13 is a member of the S100 protein family and displays calcium-binding abilities usually binding two calcium ions. This small protein has a molecular mass of approximately 11 kDa. S100A13 is expressed in a variety of tissues including the heart brain and skeletal muscle. Its expression can be altered in different cellular conditions suggesting an adaptive role in diverse physiological contexts.
Biological function summary

S100A13 influences several cellular processes related to growth and differentiation. This protein facilitates secretion of fibroblast growth factor 1 (FGF1) and interleukin-1 alpha (IL-1α) through a non-classical pathway. S100A13 does not function alone; it engages in complexes with other proteins to execute its roles. It often works together with S100A6 and calcyclin-binding protein in these secretory pathways.

Pathways

S100A13 participates in the regulation of angiogenesis and inflammation. It is involved in the FGF signal transduction pathway by affecting the externalization of FGF1 an important player in angiogenesis. Additionally S100A13 contributes to inflammation-related processes. Its activity is linked to proteins such as p53 and FGF1 integrating it into wider cellular systems.

S100A13 is implicated in cancer and chronic inflammatory conditions. Overexpression of S100A13 has links to tumor progression and aggressiveness suggesting a role in cancer. In chronic inflammation S100A13 associates with increased levels of inflammatory cytokines. It connects to proteins like FGF1 and IL-1α in these contexts linking it with pathophysiological mechanisms that underlie these conditions.
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常规信息

功能

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).

序列相似性

Belongs to the S-100 family.

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产品实验方案

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靶点信息

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).
See full target information Protein S100-A13
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