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AB123171

重组人RRAGC蛋白

Recombinant Human RRAGC protein

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Recombinant Human RRAGC protein is a Human Full Length protein, in the 1 to 399 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

查看别名

Ras-related GTP-binding protein C, Rag C, RagC, GTPase-interacting protein 2, TIB929, RRAGC

1 Images
SDS-PAGE - Recombinant Human RRAGC protein (AB123171)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RRAGC protein (AB123171)

15% SDS-PAGE showing ab123171 (3µg).

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

Mass Spec, SDS-PAGE

applications

生物活性

No

访问

Q9HB90

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAAGGGVGAGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCGHQTSASSLKALTHNGTPRNAI","proteinLength":"Full Length","predictedMolecularWeight":"46.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":399,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9HB90","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The RRAGC protein also known as Ras-related GTP-binding protein C weighs approximately 44.5 kDa. It functions mechanically as a GTPase cycling between active GTP-bound and inactive GDP-bound states. This protein is expressed in various tissues with noticeable presence in the brain and liver. RRAGC plays a role in cellular signaling and growth mechanisms by interacting with other members of the Ras superfamily.
Biological function summary

RRAGC forms a part of the heterodimeric Rag GTPase complex often teaming with its partner RRAGB. This complex acts as an important regulator in the mTORC1 signaling pathway influencing nutrient sensing and energy balance within cells. RRAGC's ability to toggle between different energy states allows it to contribute to cellular metabolism and response to external stress.

Pathways

RRAGC engages directly in the mTOR signaling pathway an important driver of cell growth and proliferation. It interacts closely with related proteins such as Raptor and mTOR kinase forming a bridge between amino acid availability and cellular growth signals. Additionally RRAGC's role connects to the autophagy pathway affecting cellular degradation processes and nutrient recycling under nutrient-deprived conditions.

The dysregulation of RRAGC's activity associates with conditions like cancer and neurodegenerative diseases. Alterations in its function may link to aberrant mTOR signaling contributing to uncontrolled cellular proliferation seen in cancers. Furthermore RRAGC and its interactions with proteins such as TSC2 (Tuberous Sclerosis Complex 2) highlight potential influences in neurodegenerative disease pathways shedding light on its involvement in conditions linked to cellular growth dysregulation.
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特殊说明

形式

Liquid

附加说明

ab123171 is purified using conventional chromatography techniques.

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常规信息

功能

Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed : 20381137, PubMed : 24095279, PubMed : 27234373, PubMed : 31601708, PubMed : 31601764, PubMed : 32612235, PubMed : 34071043, PubMed : 36697823, PubMed : 37057673). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form : RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed : 24095279, PubMed : 31601708, PubMed : 31601764, PubMed : 32868926). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed : 20381137, PubMed : 24095279, PubMed : 27234373, PubMed : 32612235, PubMed : 36697823). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed : 20381137, PubMed : 24095279, PubMed : 27234373). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3 : GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed : 32612235, PubMed : 36697823).

序列相似性

Belongs to the GTR/RAG GTP-binding protein family.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed : 20381137, PubMed : 24095279, PubMed : 27234373, PubMed : 31601708, PubMed : 31601764, PubMed : 32612235, PubMed : 34071043, PubMed : 36697823, PubMed : 37057673). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form : RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed : 24095279, PubMed : 31601708, PubMed : 31601764, PubMed : 32868926). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed : 20381137, PubMed : 24095279, PubMed : 27234373, PubMed : 32612235, PubMed : 36697823). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed : 20381137, PubMed : 24095279, PubMed : 27234373). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3 : GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed : 32612235, PubMed : 36697823).
See full target information Ras-related GTP-binding protein C
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