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AB101208

重组人 RQCD1 蛋白 (His tag N-Terminus)

Recombinant Human RQCD1 protein (His tag N-Terminus)

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Recombinant Human RQCD1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 299 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

查看别名

RCD1, RQCD1, CNOT9, CCR4-NOT transcription complex subunit 9, Cell differentiation protein RQCD1 homolog, Rcd-1

1 Images
SDS-PAGE - Recombinant Human RQCD1 protein (His tag N-Terminus) (AB101208)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RQCD1 protein (His tag N-Terminus) (AB101208)

ab101208 at 3 μg analysed by 15% SDS PAGE.

关键信息

纯度

>95% SDS-PAGE

ab101208 was purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q92600

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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搭配使用产品

Proteins & Peptides

AB80323

Recombinant human EHMT2/G9A protein (GST tag N-Terminus)

Functional Studies - Recombinant human EHMT2/G9A protein (GST tag N-Terminus) (AB80323)

  • 0
  • 0
Primary Antibodies

AB195587

Anti-CNOT7 antibody [EPR18722]

RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-CNOT7 antibody [EPR18722] (AB195587)

  • 4
  • 7
Primary Antibodies

AB312314

Anti-PABP antibody [EPR27188-86]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-PABP antibody [EPR27188-86] (AB312314)

  • 0
  • 0
Primary Antibodies

AB221151

Anti-CNOT6 antibody [EPR22022]

RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-CNOT6 antibody [EPR22022] (AB221151)

  • 3
  • 2
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMHSLATAAPVPTTLAQVDREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLKDDTTTKRWLAQLVKNLQEGQVTDPRGIPLPPQ","proteinLength":"Full Length","predictedMolecularWeight":"35.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":299,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q92600","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

RQCD1 also known as Required for Cell Differentiation 1 is a protein with an approximate mass of 34 kDa. It plays an essential role in gene expression regulation by acting as a transcriptional cofactor. RQCD1 is highly expressed in various tissues including the liver kidney and heart. The protein interacts with different transcription factors and modulates their activities which influences cellular pathways critical for cell development and differentiation.
Biological function summary

The protein RQCD1 acts as a component of the human mRNA methyltransferase-associated complex. The complex is involved in post-transcriptional modifications. Through its interaction in the complex RQCD1 contributes to RNA processing and stability further affecting gene expression outcomes. This involvement impacts cell cycle regulation and proliferation necessary for maintaining cellular homeostasis.

Pathways

The protein RQCD1 is important in the MAPK signaling pathway and Wnt signaling pathway. In these pathways it interacts with proteins like c-Fos and β-catenin influencing pathways related to cell growth and differentiation. Its presence in these pathways demonstrates the protein's role in signal transduction processes that govern various cellular responses.

Proteins like RQCD1 have shown associations with cancer and metabolic disorders. Aberrant expression or mutations in RQCD1 are linked to the development and progression of certain cancers due to its role in transcriptional regulation. Additionally this protein has connections with metabolic proteins like AMPK indicating its potential impact on disorders related to metabolic imbalance. These roles suggest that RQCD1 is a significant player in both cancer biology and metabolism-related diseases.
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常规信息

功能

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.

序列相似性

Belongs to the CNOT9 family.

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产品实验方案

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靶点信息

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.
See full target information CNOT9
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