重组人RGS10蛋白
Recombinant Human RGS10 protein
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Recombinant Human RGS10 protein is a Human Full Length protein, in the 1 to 181 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
查看别名
Regulator of G-protein signaling 10, RGS10
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human RGS10 protein (AB109947)
ab109947 at 3 ug on an SDS-PAGE gel (15%)
反应性数据
序列信息
性能和储存信息
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
RGS10 plays a role in immune responses and neural function. It is not typically part of larger protein complexes but it interacts independently with other proteins in cellular signaling pathways. In the immune system RGS10 influences various processes such as cytokine production and leukocyte function. In neurons RGS10 contributes to maintaining neural signaling by regulating neurotransmitter-related G-protein coupled receptor pathways.
Pathways
G-protein signaling pathways and the MAPK signaling pathway include RGS10 as an important regulatory protein. It modulates the G-protein coupled receptor signaling pathway an important aspect of cellular response to external stimuli. RGS10 also influences the PI3K-Akt signaling pathway by regulating upstream signaling events. These pathways involve proteins such as G alpha subunits and PI3 kinase which interact with RGS10 to control diverse physiological processes.
特殊说明
形式
Liquid
附加说明
ab109947 was purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
常规信息
功能
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed : 10608901, PubMed : 11443111, PubMed : 18434541, PubMed : 8774883, PubMed : 9353196). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed : 11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed : 9353196).
亚细胞定位
Nucleus
靶点信息
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