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重组人RFX5蛋白(ab131776)

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SDS-PAGE - Recombinant Human RFX5 protein (ab131776)

    Key features and details

    • Expression system: Wheat germ
    • Suitable for: ELISA, WB, SDS-PAGE

    描述

    • 产品名称

      重组人RFX5蛋白

    • 表达系统

      Wheat germ

    • Accession

      P48382

    • 蛋白长度

      Full length protein

    • 无动物成分

      No

    • 性质

      Recombinant

      • 种属

        Human

      • 序列

        MAEDEPDAKSPKTGGRAPPGGAEAGEPTTLLQRLRGTISKAVQNKVEGIL QDVQKFSDNDKLYLYLQLPSGPTTGDKSSEPSTLSNEEYMYAYRWIRNHL EEHTDTCLPKQSVYDAYRKYCESLACCRPLSTANFGKIIREIFPDIKARR LGGRGQSKYCYSGIRRKTLVSMPPLPGLDLKGSESPEMGPEVTPAPRDEL VEAACALTCDWAERILKRSFSSIVEVARFLLQQHLISARSAHAHVLKAMG LAEEDEHAPRERSSKPKNGLENPEGGAHKKPERLAQPPKDLEARTGAGPL ARGERKKSVVESSAPGANNLQVNALVARLPLLLPRAPRSLIPPIPVSPPI LAPRLSSGALKVATLPLSSRAGAPPAAVPIINMILPTVPALPGPGPGPGR APPGGLTQPRGTENREVGIGGDQGPHDKGVKRTAEVPVSEASGQAPPAKA AKQDIEDTASDAKRKRGRPRKKSGGSGERNSTPLKSAAAMESAQSSRLPW ETWGSGGEGNSAGGAERPGPMGEAEKGAVLAQGQGDGTVSKGGRGPGSQH TKEAEDKIPLVPSKVSVIKGSRSQKEAFPLAKGEVDTAPQGNKDLKEHVL QSSLSQEHKDPKATPP

      • 预测分子量

        92 kDa including tags

      • 氨基酸

        1 to 616

    相关产品

    技术指标

    Our Abpromise guarantee covers the use of ab131776 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • 应用

      ELISA

      Western blot

      SDS-PAGE

    • 形式

      Liquid
    • Concentration information loading...

    制备和贮存

    • 稳定性和存储

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    常规信息

    • 别名

      • DNA binding protein RFX 5
      • DNA binding protein RFX5
      • DNA-binding protein RFX5
      • Influences HLA class II expression
      • Regulatory factor X 5
      • Regulatory factor X subunit 5
      • Regulatory factor X, 5 (influences HLA class II expression)
      • RFX 5
      • RFX5
      • Rfx5 protein
      • RFX5_HUMAN
      see all

    • 功能

      Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.

    • 组织特异性

      Ubiquitous.

    • 疾病相关

      Defects in RFX5 are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.

    • 序列相似性

      Belongs to the RFX family.
      Contains 1 RFX-type winged-helix DNA-binding domain.

    • 结构域

      The N-terminus is required for dimer formation, association with RFXANK and RFXAP, assembly of the RFX complex, and for binding of this complex to its X box target site in the MHC-II promoter. The C-terminus mediates cooperative binding between the RFX complex and NF-Y.

    • 翻译后修饰

      Phosphorylated.

    • 细胞定位

      Nucleus.
    • Information by UniProt

    图片

    • SDS-PAGE - Recombinant Human RFX5 protein (ab131776)
      SDS-PAGE - Recombinant Human RFX5 protein (ab131776)
      12.5% SDS-PAGE analysis of ab131776 stained with Coomassie Blue.

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (0)

    发表研究结果有使用 ab131776？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab131776 尚未被引用在任何文献中。

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