重组人 Renalase 蛋白 (GST tag N-Terminus)
Recombinant Human Renalase protein (GST tag N-Terminus)
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Recombinant Human Renalase protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 342 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
查看别名
C10orf59, RNLS, Renalase, Monoamine oxidase-C, MAO-C
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human Renalase protein (AB132381)
12.5% SDS-PAGE analysis of ab132381 stained with Coomassie Blue.
反应性数据
序列信息
性能和储存信息
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Renalase impacts the cardiovascular system through its enzymatic function that reduces systemic catecholamine levels. It has been shown the protein interacts with catecholamines beyond the boundaries of a simple enzymatic reaction. Renalase may form complexes with other enzymes that participate in detoxifying catecholamines. Researchers have studied its effects on catecholamine-related stress responses highlighting a potential modulatory function beyond simple substrate degradation.
Pathways
The metabolism of catecholamines involves Renalase in the regulation of the sympathetic nervous system and its associated pathways. Renalase fits into the catecholamine degradation pathway where it works alongside other enzymes such as monoamine oxidase which also breaks down neurotransmitters. These actions influence the broader systemic pathways associated with cardiovascular health by maintaining a balance in neurotransmitter levels and resultant blood pressure regulation.
特殊说明
形式
Liquid
常规信息
功能
Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
序列相似性
Belongs to the renalase family.
靶点信息
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