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AB132381

重组人 Renalase 蛋白 (GST tag N-Terminus)

Recombinant Human Renalase protein (GST tag N-Terminus)

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Recombinant Human Renalase protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 342 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

查看别名

C10orf59, RNLS, Renalase, Monoamine oxidase-C, MAO-C

1 Images
SDS-PAGE - Recombinant Human Renalase protein (AB132381)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Renalase protein (AB132381)

12.5% SDS-PAGE analysis of ab132381 stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, ELISA, SDS-PAGE

applications

生物活性

No

访问

Q5VYX0

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

序列信息

[{"sequence":"MAQVLIVGAGMTGSLCAALLRRQTSGPLYLAVWDKADDSGGRMTTACSPHNPQCTADLGAQYITCTPHYAKKHQRFYDELLAYGVLRPLSSPIEGMVMKEGDCNFVAPQGISSIIKHYLKESGAEVYFRHRVTQINLRDDKWEVSKQTGSPEQFDLIVLTMPVPEILQLQGDITTLISECQRQQLEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENILPGLPQPIATKCQKWRHSQVTNAAANCPGQMTLHHKPFLACGGDGFTQSNFDGCITSALCVLEALKNYI","proteinLength":"Full Length","predictedMolecularWeight":"64.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":342,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q5VYX0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Renalase also known as RNLS is a flavoprotein that catalyzes the oxidation of catecholamines such as dopamine and norepinephrine. It has a mass of approximately 37 kDa. The protein is expressed in the kidney heart and other tissues including the liver and brain. Its enzymatic activity helps in regulating blood pressure and cardiac function by metabolizing circulating monoamines.
Biological function summary

Renalase impacts the cardiovascular system through its enzymatic function that reduces systemic catecholamine levels. It has been shown the protein interacts with catecholamines beyond the boundaries of a simple enzymatic reaction. Renalase may form complexes with other enzymes that participate in detoxifying catecholamines. Researchers have studied its effects on catecholamine-related stress responses highlighting a potential modulatory function beyond simple substrate degradation.

Pathways

The metabolism of catecholamines involves Renalase in the regulation of the sympathetic nervous system and its associated pathways. Renalase fits into the catecholamine degradation pathway where it works alongside other enzymes such as monoamine oxidase which also breaks down neurotransmitters. These actions influence the broader systemic pathways associated with cardiovascular health by maintaining a balance in neurotransmitter levels and resultant blood pressure regulation.

Renalase has been associated with hypertension due to its role in catecholamine metabolism. Abnormal Renalase function can contribute to increased circulating catecholamines leading to elevated blood pressure. Additionally studies have suggested a link between Renalase and chronic kidney disease where alterations in Renalase activity may exacerbate kidney dysfunction. The relationship between Renalase and proteins like angiotensin-converting enzyme (ACE) further hints at its potential involvement in blood pressure regulation and renal pathology.

特殊说明

形式

Liquid

常规信息

功能

Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.

序列相似性

Belongs to the renalase family.

产品实验方案

靶点信息

Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
See full target information RNLS

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