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AB227416

重组人 RAET1E 蛋白 (Fc tag C-Terminus + His tag C-Terminus)

Recombinant Human RAET1E protein (Fc tag C-Terminus + His tag C-Terminus)

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Recombinant Human RAET1E protein (Fc tag C-Terminus + His tag C-Terminus) is a Human Fragment protein, in the 31 to 225 aa range, expressed in Baculovirus infected insect cells, with >85%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

查看别名

LETAL, N2DL4, ULBP4, UNQ1867/PRO4303, RAET1E, Retinoic acid early transcript 1E, Lymphocyte effector toxicity activation ligand, NKG2D ligand 4, RAE-1-like transcript 4, UL16-binding protein 4, N2DL-4, NKG2DL4

1 Images
SDS-PAGE - Recombinant Human RAET1E protein (Fc tag C-Terminus + His tag C-Terminus) (AB227416)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human RAET1E protein (Fc tag C-Terminus + His tag C-Terminus) (AB227416)

15% SDS-PAGE analysis of 3 μg ab227416.

MW 57-70 kDa (SDS-PAGE under reducing conditions).

关键信息

纯度

>85% SDS-PAGE

Affinity purified

内毒素水平

< 1 EU/µg

表达系统

Baculovirus infected insect cells

标签

Fc tag C-Terminus His tag C-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q8TD07

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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搭配使用产品

Primary Antibodies

AB95202

Anti-RAET1E antibody [79/6/13/16]

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Assay Kits

AB314718

Human RAET1E ELISA Kit

Sandwich ELISA - Human RAET1E ELISA Kit (AB314718)

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Proteins & Peptides

AB163631

Recombinant Human GBA2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human GBA2 protein (GST tag N-Terminus) (AB163631)

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  • 0
Proteins & Peptides

AB108130

Recombinant Human SYT1 protein (His tag C-Terminus)

SDS-PAGE - Recombinant Human SYT1 protein (His tag C-Terminus) (AB108130)

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  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

This product was previously labelled as ULBP4
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序列信息

[{"linker":null,"sequence":"ADPHSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLPDVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"49.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":225,"aminoAcidStart":31,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"Q8TD07","tags":[{"tag":"Fc","terminus":"C-Terminus"},{"tag":"His","terminus":"C-Terminus"}]}]
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

RAET1E also known as UL16-binding protein 4 (ULBP4) is a member of the MHC class I-related molecules. It has a molecular mass of approximately 31 kDa. RAET1E is part of the family of proteins that acts as a ligand for the NKG2D receptor found on the surface of natural killer (NK) cells. In terms of expression RAET1E is present on the surface of various cell types especially in stressed transformed or virus-infected cells where it signals cellular distress to immune cells.
Biological function summary

RAET1E plays a role in immune surveillance. It is involved in the activation of NK cells when it binds to the NKG2D receptor. This interaction is part of the body's defense mechanism against transformed or infected cells. RAET1E operates in isolation rather than as part of a larger protein complex which allows it to independently initiate the immune response when detecting harmful cells.

Pathways

RAET1E functions within the innate immune response pathway. It works closely with the NKG2D signaling pathway which is important for the activation of cytotoxic activities in immune cells. RAET1E through its binding to NKG2D facilitates the destruction of malignant cells. This connection places RAET1E alongside other similar NKG2D ligands such as MIC and other ULBP family proteins which contribute to the activation of NK and T cells.

RAET1E is linked to various cancer types and infectious diseases. Its expression on the surface of tumor cells can signal NK cells to target and destroy these potentially harmful cells. In certain cancers the loss or reduction of RAET1E expression may allow tumor cells to escape immune detection. In viral infections the upregulation of RAET1E on infected cells assists in the clearance of viruses by NK cells. Both in cancer and viral infections proteins like RAET1E and NKG2D play an important part in the immune system's defensive strategies.
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常规信息

功能

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

序列相似性

Belongs to the MHC class I family.

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产品实验方案

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靶点信息

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
See full target information RAET1E
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