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AB115720

重组人 Rab18 蛋白 (T7 tag N-Terminus)

Recombinant Human Rab18 protein (T7 tag N-Terminus)

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Recombinant Human Rab18 protein (T7 tag N-Terminus) is a Human Full Length protein, in the 1 to 206 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

查看别名

Ras-related protein Rab-18, RAB18

1 Images
SDS-PAGE - Recombinant Human Rab18 protein (T7 tag N-Terminus) (AB115720)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Rab18 protein (T7 tag N-Terminus) (AB115720)

15% SDS-PAGE showing ab115720 at approximately 24.5kDa (3μg).

关键信息

纯度

>90% SDS-PAGE

ab115720 was purified using conventional chromatography techniques.

表达系统

Escherichia coli

标签

T7 tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q9NP72

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.5 Constituents: 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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搭配使用产品

Proteins & Peptides

AB174416

Recombinant Human UQCRH protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human UQCRH protein (His tag N-Terminus) (AB174416)

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  • 0
Primary Antibodies

AB182764

Anti-Rab18 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Rab18 antibody (AB182764)

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Proteins & Peptides

AB112300

Recombinant Human Huntingtin protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Huntingtin protein (GST tag N-Terminus) (AB112300)

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Proteins & Peptides

AB132523

Recombinant Human PGRMC1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human PGRMC1 protein (GST tag N-Terminus) (AB132523)

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  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"MASMTGGQQMGRGSHMDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKAKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESENQNKGVKLSHREEGQGGGACGGYCSVL","proteinLength":"Full Length","predictedMolecularWeight":"24.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":206,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NP72","tags":[{"tag":"T7","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Rab18 also known as RAB18A or RAB18 is a member of the Rab GTPase family a group of proteins involved in intracellular vesicle trafficking. Rab18 is approximately 23 kDa in mass. Researchers find Rab18 expressed widely in various tissues including the brain liver and adipose tissue. As a small GTPase Rab18 switches between an inactive GDP-bound state and an active GTP-bound state regulating membrane trafficking and fusion processes.
Biological function summary

The functions of Rab18 extend beyond simple vesicular transport. Rab18 interacts with lipid droplets and the endoplasmic reticulum influencing lipid metabolism and storage. It is sometimes present in a complex with proteins like TBC1D20 which acts as a GAP (GTPase-activating protein) that further regulates Rab18’s activity. Through these interactions Rab18 influences lipid homeostasis and endoplasmic reticulum organization adding a layer of control to cellular lipid balance.

Pathways

Rab18 participates in the regulation of lipid droplet growth and maturation linking it to lipid metabolism pathways. Its activity plays a role in the tethering of lipid droplets to the endoplasmic reticulum relating it functionally to proteins such as Seipin. Additionally Rab18 is involved in intracellular transport pathways where it cooperates with other Rab proteins like Rab3 and Rab10 to facilitate membrane trafficking and organelle dynamics.

Rab18 associations are evident in conditions like Warburg Micro syndrome and intellectual disability. Warburg Micro syndrome characterized by eye and brain abnormalities emerges from mutations affecting Rab18 or its interacting partners like RAB3GAP. Similarly Rab18’s involvement in lipid metabolism connects it with metabolic disorders where lipid storage and synthesis disruptions play a role. This links the functionality of Rab18 in cellular processes to broader impacts on human health.
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常规信息

功能

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed : 24891604, PubMed : 30970241). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed : 24891604, PubMed : 30970241). RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (PubMed : 30970241). Also required for maintaining endoplasmic reticulum structure (PubMed : 24891604). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (PubMed : 21473985).

序列相似性

Belongs to the small GTPase superfamily. Rab family.

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产品实验方案

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靶点信息

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed : 24891604, PubMed : 30970241). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed : 24891604, PubMed : 30970241). RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (PubMed : 30970241). Also required for maintaining endoplasmic reticulum structure (PubMed : 24891604). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (PubMed : 21473985).
See full target information Ras-related protein Rab-18
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