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AB100986

重组人 QPRT 蛋白 (His tag N-Terminus)

Recombinant Human QPRT protein (His tag N-Terminus)

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Recombinant Human QPRT protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 297 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

查看别名

Nicotinate-nucleotide pyrophosphorylase [carboxylating], Quinolinate phosphoribosyltransferase [decarboxylating], QAPRTase, QPRTase, QPRT

1 Images
SDS-PAGE - Recombinant Human QPRT protein (His tag N-Terminus) (AB100986)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human QPRT protein (His tag N-Terminus) (AB100986)

ab100986 at 3 μg being analysed by 15% SDS PAGE.

关键信息

纯度

>95% SDS-PAGE

purified by using conventional chromatography techniques.

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q15274

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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搭配使用产品

Primary Antibodies

AB171944

Anti-QPRT antibody [EPR11941(B)]

RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-QPRT antibody [EPR11941(B)] (AB171944)

  • 0
  • 0
Assay Kits

AB284020

Human QPRT ELISA Kit

Sandwich ELISA - Human QPRT ELISA Kit (AB284020)

  • 0
  • 0
Sample Prep & Detection Kits

AB193970

Extraction Buffer 5X PTR

SimpleStep

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Assay Kits

AB210890

Mouse Albumin Matched Antibody Pair Kit

Recombinant

Sandwich ELISA - Mouse Albumin Matched Antibody Pair Kit (AB210890)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFALKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH","proteinLength":"Full Length","predictedMolecularWeight":"32.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":297,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q15274","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

QPRT also known as Nicotinate-nucleotide pyrophosphorylase [carboxylating] or Quinolinate phosphoribosyltransferase functions as an important enzyme in the kynurenine pathway a metabolic pathway leading to the production of nicotinamide adenine dinucleotide (NAD+). The enzyme catalyzes the conversion of quinolinate to nicotinic acid mononucleotide. QPRT has a molecular mass of approximately 34 kDa. It is expressed in various tissues most notably in the liver kidney and brain.
Biological function summary

QPRT influences the synthesis of NAD+ which is essential for cellular redox reactions and energy metabolism. The enzyme operates as a monomer and does not typically form part of a larger complex. However its activity is important in maintaining NAD+ levels which can impact a wide range of cellular processes such as DNA repair signal transduction and metabolism.

Pathways

QPRT holds a significant role in the kynurenine pathway and NAD+ biosynthesis. This pathway includes several enzymes such as kynurenine 3-monooxygenase and kynureninase which collaboratively contribute to the degradation of tryptophan ultimately affecting the levels of important coenzymes and neurotransmitters. The NAD+ biosynthesis pathway involving QPRT also interacts with pathways for ATP generation connecting with other metabolic processes.

QPRT's malfunction links to neurological disorders such as Alzheimer's disease due to its role in NAD+ metabolism and potential effects on neuronal health and energy supply. Additionally alterations in QPRT activity have associations with liver diseases considering its expression and function in metabolic pathways within hepatic tissues. Interaction with proteins like kynurenine aminotransferase highlights its involvement in maintaining metabolic balance within these conditions.
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常规信息

功能

Involved in the catabolism of quinolinic acid (QA).

序列相似性

Belongs to the NadC/ModD family.

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产品实验方案

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靶点信息

Involved in the catabolism of quinolinic acid (QA).
See full target information Nicotinate-nucleotide pyrophosphorylase [carboxylating]
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