重组人PTHLH蛋白(ab51706)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Tags: His tag N-Terminus
- Suitable for: HPLC, SDS-PAGE
描述
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产品名称
重组人PTHLH蛋白
参阅全部 PTHLH 蛋白酶 -
纯度
> 95 % SDS-PAGE.
>98% by SDS-PAGE and HPLC analysis. Endotoxin level is <0.1 ng per µg of PTHrP. Sterile filtered. -
表达系统
Escherichia coli -
Accession
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蛋白长度
Protein fragment -
无动物成分
No -
性质
Recombinant -
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种属
Human -
氨基酸
37 to 122 -
标签
His tag N-Terminus
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技术指标
Our Abpromise guarantee covers the use of ab51706 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
HPLC
SDS-PAGE
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形式
Lyophilized -
补充说明
This product is manufactured by BioVision, an Abcam company and was previously called 4651 PTHrP, human recombinant. 4651-50 is the same size as the 50 µg size of ab51706.
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Constituent: PBS
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复溶Reconstitute in water to a concentration of 1.0 mg/ml.
常规信息
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别名
- HHM
- MGC14611
- Osteostatin
see all -
功能
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
Osteostatin is a potent inhibitor of osteoclastic bone resorption. -
组织特异性
Ubiquitous. Also expressed in the mammary gland. -
疾病相关
Brachydactyly E2 -
序列相似性
Belongs to the parathyroid hormone family. -
翻译后修饰
There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. -
细胞定位
Cytoplasm. Nucleus. Secreted. - Information by UniProt
图片
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HPLC - Recombinant Human PTHLH protein (ab51706)
HPLC analyses of rh PTHrP. 200 µg of rhPTHrP were loaded on Phenomenex Gemini C18 column (25 x 4.6 mm 5 µm). The column was eluted with a 50 minute gradient of AcCN from 5 to 95% in 0.1% TFA at 1 ml/min.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (0)
ab51706 尚未被引用在任何文献中。
