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AB196412

重组人PRDM12蛋白

Recombinant Human PRDM12 protein

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Recombinant Human PRDM12 protein is a Human Fragment protein, in the 2 to 243 aa range, expressed in Escherichia coli, with >50%, suitable for SDS-PAGE.

查看别名

PFM9, PRDM12, PR domain zinc finger protein 12, PR domain-containing protein 12

1 Images
SDS-PAGE - Recombinant Human PRDM12 protein (AB196412)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PRDM12 protein (AB196412)

4-20% SDS-PAGE analysis of 2 μg ab196412 with Coomassie staining.

关键信息

纯度

>50% SDS-PAGE

表达系统

Escherichia coli

标签

GST tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q9H4Q4

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDLEVLFQ^GPLGSMGSVLPAEALVLKTGLKAPGLALAEVITSDILHSFLYGRWRNVLGEQLFEDKSHHASPKTAFTAEVLAQSFSGEVQKLSSLVLPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIPGVPGLEEDQKKNKHEDFHPADSAAGPAGRM","proteinLength":"Fragment","predictedMolecularWeight":"54 kDa","actualMolecularWeight":null,"aminoAcidEnd":243,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9H4Q4","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PRDM12 also known as PR domain containing 12 is a transcriptional regulator believed to have a mass of approximately 88 kDa. It functions mechanically by modulating gene expression through histone methylation. PRDM12 localizes in the nucleus and is primarily expressed in the nervous system notably in sensory neurons. It acts by interacting with other factors to influence the chromatin structure thereby modifying how genes get transcribed.
Biological function summary

PRDM12 plays a significant role in neural development and differentiation. It is a part of the PRDM family which is involved in various cellular processes through its interaction with cofactors. PRDM12 interacts to modulate neural gene expression contributing to the formation and maintenance of neural tissues. It does not function alone and requires protein partners forming complexes to execute its regulating tasks effectively within the cell.

Pathways

The activity of PRDM12 integrates into developmental signaling networks including the Notch and Wnt pathways. These pathways are critical for neural differentiation and cellular fate decision indicating PRDM12's involvement in neurogenesis. It interacts with proteins like Notch1 and β-catenin—key components in these pathways—to regulate downstream effects related to nerve cell specification and growth.

Mutations or dysregulation of PRDM12 have connections to congenital insensitivity to pain where patients cannot feel physical pain. This condition highlights PRDM12's importance in sensory neuron function. Another condition associated is peripheral neuropathy where the integrity of peripheral nerves is compromised. Here interactions with the TrkA protein which influences nerve growth factor receptor binding showcase PRDM12's role in disease contexts related to nerve health and functionality.
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特殊说明

形式

Liquid

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常规信息

功能

Involved in the positive regulation of histone H3-K9 dimethylation.

序列相似性

Belongs to the class V-like SAM-binding methyltransferase superfamily.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Involved in the positive regulation of histone H3-K9 dimethylation.
See full target information PRDM12
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