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AB131822

重组人 PPP2R5C 蛋白 (GST tag N-Terminus)

Recombinant Human PPP2R5C protein (GST tag N-Terminus)

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Recombinant Human PPP2R5C protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 524 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

查看别名

KIAA0044, PPP2R5C, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, PP2A B subunit isoform B'-gamma, PP2A B subunit isoform B56-gamma, PP2A B subunit isoform PR61-gamma, PP2A B subunit isoform R5-gamma, Renal carcinoma antigen NY-REN-29

1 Images
SDS-PAGE - Recombinant Human PPP2R5C protein (GST tag N-Terminus) (AB131822)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PPP2R5C protein (GST tag N-Terminus) (AB131822)

12.5% SDS-PAGE stained with Coomassie Blue showing ab131822 at approximately 87.5 kDa.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

SDS-PAGE, WB, ELISA

applications

生物活性

No

访问

Q13362

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>(Recombinant protein).</p>" } } }
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序列信息

[{"sequence":"MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAHQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR","proteinLength":"Full Length","predictedMolecularWeight":"87.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":524,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q13362","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The protein phosphatase 2 regulatory subunit B' gamma also known as PPP2R5C is a regulatory component of the protein phosphatase 2A (PP2A) holoenzyme. PPP2R5C has a molecular weight of approximately 59 kDa. This protein shows expression in various tissues including brain kidney spleen and liver. PPP2R5C serves as a modulator by altering the substrate selectivity or catalytic activity of the PP2A core enzyme which consists of a catalytic subunit and a structural subunit.
Biological function summary

The protein plays a role in mediating cellular processes through its participation as part of the PP2A holoenzyme complex. PP2A regulates various cellular activities including cell cycle progression apoptosis and signal transduction. PPP2R5C contributes to these biological processes by modulating enzyme activity and directing the PP2A holoenzyme to specific subcellular compartments or substrates. This makes PPP2R5C essential for maintaining cellular homeostasis and response to environmental signals.

Pathways

PPP2R5C functions in key signaling pathways such as the MAPK/ERK pathway and the PI3K/AKT pathway. In the MAPK/ERK pathway PPP2R5C affects phosphorylation states and downstream signaling outcomes. The protein also interacts with other components such as AKT enabling regulation of cellular growth metabolism and survival mechanisms. These interactions define the influence of PPP2R5C on signal propagation and impact the overall cellular response.

Alterations in PPP2R5C have been implicated in cancer and neurodegenerative diseases. In cancer abnormal PP2A activity linked with PPP2R5C affects cell cycle regulation and tumorigenesis interacting with cancer-related pathways and proteins like MYC. In neurodegenerative diseases dysfunctions in signaling mechanisms where PPP2R5C is involved contribute to disease progression affecting proteins related to neuron survival and function. Understanding the role of PPP2R5C in these diseases provides insight into potential therapeutic targets.
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特殊说明

形式

Liquid

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常规信息

功能

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.

序列相似性

Belongs to the phosphatase 2A regulatory subunit B56 family.

翻译后修饰

Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
See full target information PPP2R5C
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搭配使用产品

Primary Antibodies

AB264338

Anti-PPP2R5C antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PPP2R5C antibody (AB264338)

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Cell Lines & Lysates

AB269620

Human PPP2R5C knockout A-431 cell line

Next Generation Sequencing - Human PPP2R5C knockout A-431 cell line (AB269620)

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Cell Lines & Lysates

AB258601

Human PPP2R5C knockout HEK-293T cell lysate

Sanger Sequencing - Human PPP2R5C knockout HEK-293T cell lysate (AB258601)

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