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AB236342

重组人PNMA1蛋白(Tagged)

Recombinant Human PNMA1 protein (Tagged)

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Recombinant Human PNMA1 protein (Tagged) is a Human Full Length protein, in the 1 to 353 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

查看别名

MA1, PNMA1, Paraneoplastic antigen Ma1, 37 kDa neuronal protein, Neuron- and testis-specific protein 1

1 Images
SDS-PAGE - Recombinant Human PNMA1 protein (Tagged) (AB236342)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PNMA1 protein (Tagged) (AB236342)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab236342.

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

10x His tag N-Terminus B2M-JD tag N-Terminus Myc tag C-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q8ND90

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDEAEIEETLQAAMPQVSYRMLGRMFWREENAKAALLELTGAVDYAAIPREMPGKGGVWKVLFKPPTSDAEFLERLHLFLAREGWTVQDVARVLGFQNPTPTPGPEMPAEMLNYILDNVIQPLVESIWYKRLTLFSGRDIPGPGEETFDPWLEHTNEVLEEWQVSDVEKRRRLMESLRGPAADVIRILKSNNPAITTAECLKALEQVFGSVESSRDAQIKFLNTYQNPGEKLSAYVIRLEPLLQKVVEKGAIDKDNVNQARLEQVIAGANHSGAIRRQLWLTGAGEGPAPNLFQLLVQIREEEAKEEEEEAEATLLQLGLEGHF","proteinLength":"Full Length","predictedMolecularWeight":"46.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":353,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8ND90","tags":[{"tag":"10x His","terminus":"N-Terminus"},{"tag":"B2M-JD","terminus":"N-Terminus"},{"tag":"Myc","terminus":"C-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PNMA1 known as Paraneoplastic Ma Antigen 1 is a protein involved in immunological processes. It has a molecular mass of approximately 40 kDa. This protein is expressed in various tissues including the brain and testis. It has notable relevance in certain neurological contexts associated with paraneoplastic syndromes. Studies have indicated that PNMA1 might play a role in cellular mechanisms involving immune surveillance or response due to its expression pattern and involvement in related pathways.
Biological function summary

PNMA1 interacts within cellular environments likely contributing to neuronal signaling or maintenance. It is suspected to be a part of a larger protein complex which may facilitate its role in modulating immune responses at the cellular level. As such it plays a role in the fine-tuning of immune system activities particularly in the context of tumors where altered expression patterns have been observed. Its presence in such pathway indicates a possible contribution to cellular defense mechanisms.

Pathways

PNMA1 is tied to the immune and neuronal communication paths within the human body. It integrates into the antigen processing and presentation pathway a critical function for recognizing and responding to tumor antigens. Its interactions with related proteins such as PNMA2 and PNMA3 suggest a broader set of functions in immune system regulation and tumor surveillance revealing the interconnected nature of these pathways in maintaining cellular homeostasis and defense.

PNMA1 has associations with paraneoplastic neurological syndromes and testicular cancer. These associations underline its importance in autoimmune responses elicited against nervous system antigens when expressed aberrantly in tumors. PNMA1 interacts with specific antibodies targeting neuronal tissue in paraneoplastic conditions linking it to disease manifestation. Its connection to PNMA2 and other neural-specific antigens suggests a broader spectrum of involvement in neurological immune disorders emphasizing the need for further investigation into its pathological significance.
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特殊说明

形式

Liquid

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常规信息

序列相似性

Belongs to the PNMA family.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

See full target information PNMA1
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搭配使用产品

Reagents, Controls & Accessories

AB133411

Low Fluorescence Western Membrane (PVDF)

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Proteins & Peptides

AB276438

Recombinant Human NRXN3 protein (His tag)

SDS-PAGE - Recombinant Human NRXN3 protein (His tag) (AB276438)

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Proteins & Peptides

AB237002

Recombinant Human Titin protein (Tagged)

SDS-PAGE - Recombinant Human Titin protein (Tagged) (AB237002)

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Proteins & Peptides

AB48757

Recombinant Human Recoverin protein (Tag Free)

SDS-PAGE - Recombinant Human Recoverin protein (Tag Free) (AB48757)

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Secondary Antibodies

AB125912

Rabbit monoclonal [H26-10] Anti-Human IgG1 H&L

RabMAb|Recombinant

ELISA - Rabbit monoclonal [H26-10] Anti-Human IgG1 H&L (AB125912)

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