JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB176077

重组人 PMF-1 蛋白 (denatured) (His tag N-Terminus)

Recombinant Human PMF-1 protein (denatured) (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human PMF-1 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 211 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

查看别名

Polyamine-modulated factor 1, PMF-1, PMF1

1 Images
SDS-PAGE - Recombinant Human PMF-1 protein (denatured) (His tag N-Terminus) (AB176077)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PMF-1 protein (denatured) (His tag N-Terminus) (AB176077)

15% SDS-PAGE analysis of ab176077 (3μg).

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q6P1K2

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris-HCl buffer

storage-buffer

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAEASSANLGSGCEEKRHEGSSSESVPPGTTISRVKLLDTMVDTFLQKLVAAGSYQRFTDCYKCFYQLQPAMTQQIYDKFIAQLQTSIREEISDIKEEGNLEAVLNALDKIVEEGKVRKEPAWRPSGIPEKDLHSVMAPYFLQQRDTLRRHVQKQEAENQQLADAVLAGRRQVEELQLQVQAQQQAWQVRSPAVQSPAKVQPLCPSRRAAR","proteinLength":"Full Length","predictedMolecularWeight":"26.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":211,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q6P1K2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PMF-1 also recognized as Polyamine-modulated factor 1 is a protein with a molecular mass of around 63 kDa. It plays a mechanical role in transcriptional regulation by interacting with other proteins and DNA sequences. PMF-1 is expressed mainly in the nucleus of cells across various tissues. It partners with other transcription factors modulating gene expression essential for cellular growth and differentiation. This interaction underlines its importance in transcriptional control.
Biological function summary

PMF-1 engages in modifying transcriptional responses by forming part of the TCF/LEF transcription factor complex. This complex influences the expression of genes involved in cellular proliferation and differentiation. PMF-1 functions by binding to specific DNA sequences enhancing or repressing the transcription of target genes. Through these actions it serves as a regulatory hub for controlling numerous cellular responses including but not limited to cell cycle progression and apoptosis.

Pathways

PMF-1 interacts significantly within the Wnt signaling pathway. This pathway is pivotal for regulating cellular processes related to development and growth. PMF-1 associates with proteins such as β-catenin facilitating the transcriptional activation of Wnt target genes. Through this pathway PMF-1 helps transmit signals that dictate cellular fate decisions illustrating its importance in maintaining physiological balance.

PMF-1 has notable implications in cancer and neurodegenerative conditions. In cancer its association with the Wnt signaling pathway implies roles in cell proliferation and tumor progression. The interaction with β-catenin further solidifies its connection to oncogenic processes. In neurodegenerative disorders altered PMF-1 activity can influence neuronal growth and survival implicating it in pathologies like Alzheimer's disease through dysregulated transcriptional responses.
style
left-column

特殊说明

形式

Liquid

style
left-column

常规信息

功能

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.

亚细胞定位

Nucleus

style
left-column

产品实验方案

style
left-column

靶点信息

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.
See full target information PMF1
style
left-column
style
left-column
style
right-column

搭配使用产品

Proteins & Peptides

AB174559

Recombinant Human SSSCA1 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human SSSCA1 protein (denatured) (His tag N-Terminus) (AB174559)

  • 0
  • 0
Proteins & Peptides

AB177632

Recombinant Human Ubiquinol-Cytochrome C Reductase Core Protein I (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human Ubiquinol-Cytochrome C Reductase Core Protein I (denatured) (His tag N-Terminus) (AB177632)

  • 0
  • 0
Proteins & Peptides

AB176082

Recombinant Human CGT protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human CGT protein (denatured) (His tag N-Terminus) (AB176082)

  • 0
  • 0
Proteins & Peptides

AB174417

Recombinant Human TIMM8A/DDP protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human TIMM8A/DDP protein (His tag N-Terminus) (AB174417)

  • 0
  • 0

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com