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AB101666

重组人 PITPN 蛋白 (His tag N-Terminus)

Recombinant Human PITPN protein (His tag N-Terminus)

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(1 Publication)

Recombinant Human PITPN protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 270 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

查看别名

PITPN, PITPNA, Phosphatidylinositol transfer protein alpha isoform, PI-TP-alpha, PtdIns transfer protein alpha, PtdInsTP alpha

1 Images
SDS-PAGE - Recombinant Human PITPN protein (His tag N-Terminus) (AB101666)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PITPN protein (His tag N-Terminus) (AB101666)

15% SDS-PAGE analysis of 3μg ab101666.

关键信息

纯度

>95% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q00169

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0292% EDTA, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMVLLKEYRVILPVSVDEYQVGQLYSVAEASKNETGGGEGVEVLVNEPYEKDGEKGQYTHKIYHLQSKVPTFVRMLAPEGALNIHEKAWNAYPYCRTVITNEYMKEDFLIKIETWHKPDLGTQENVHKLEPEAWKHVEAVYIDIADRSQVLSKDYKAEEDPAKFKSIKTGRGPLGPNWKQELVNQKDCPYMCAYKLVTVKFKWWGLQNKVENFIHKQERRLFTNFHRQLFCWLDKWVDLTMDDIRRMEEETKRQLDEMRQKDPVKGMTADD","proteinLength":"Full Length","predictedMolecularWeight":"33.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":270,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q00169","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PITPN also known as phosphatidylinositol transfer protein alpha (PITPα) plays an important role in lipid signaling by transferring phosphatidylinositol and phosphatidylcholine between membranes. PITPN is a 35 kDa protein expressed in various tissues with significant levels in the brain and liver. It carries out its mechanical function by binding lipids within its hydrophobic pocket facilitating their transport between cellular membranes which is important for maintaining lipid equilibrium.
Biological function summary

PITPN ensures proper signal transduction and intracellular trafficking. It forms part of a complex that regulates the transfer and distribution of phospholipids. This activity is important for membrane dynamics impacting cell communication and growth. Moreover PITPN enables the formation of phosphoinositides which are essential for activating important signaling pathways related to cellular functions.

Pathways

PITPN integrates into key phosphatidylinositol signaling pathways. These pathways are critical for producing phosphoinositide second messengers that modulate a variety of cell processes. For example PITPN collaborates with proteins such as phospholipase C which operates in inositol phosphate production. This cooperation allows for careful coordination of cellular responses such as cytoskeletal rearrangement and membrane trafficking.

Abnormal PITPN function links to neural and metabolic disorders. Mutations in PITPN can result in neurological issues such as neurodegenerative diseases due to disrupted lipid homeostasis in the brain. Furthermore PITPN's interaction with proteins like insulin receptor substrates relates to insulin resistance and diabetes development. These connections highlight PITPN's potential as a biomarker or therapeutic target for managing these conditions.
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特殊说明

形式

Liquid

附加说明

ab101666 was purified using conventional chromatography techniques.

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常规信息

功能

Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed : 10531358, PubMed : 14962392, PubMed : 15522822, PubMed : 18636990, PubMed : 22822086). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (PubMed : 15522822, PubMed : 22822086). Preference order for PC is C16 : 1 > C16 : 0 > C18 : 1 > C18 : 0 > C20 : 4 and for PI is C16 : 1 > C16 : 0 > C18 : 1 > C18 : 0 > C20 : 4 > C20 : 3 (PubMed : 22822086).

序列相似性

Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed : 10531358, PubMed : 14962392, PubMed : 15522822, PubMed : 18636990, PubMed : 22822086). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (PubMed : 15522822, PubMed : 22822086). Preference order for PC is C16 : 1 > C16 : 0 > C18 : 1 > C18 : 0 > C20 : 4 and for PI is C16 : 1 > C16 : 0 > C18 : 1 > C18 : 0 > C20 : 4 > C20 : 3 (PubMed : 22822086).
See full target information PITPNA
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Vaccines 8: PubMed32046307

2020

A Novel Combined Scientific and Artistic Approach for the Advanced Characterization of Interactomes: The Akirin/Subolesin Model.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Artigas-Jerónimo,Juan J Pastor Comín,Margarita Villar,Marinela Contreras,Pilar Alberdi,Israel León Viera,Leandro Soto,Raúl Cordero,James J Valdés,Alejandro Cabezas-Cruz,Agustín Estrada-Peña,José de la Fuente
View all publications
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搭配使用产品

Reagents, Controls & Accessories

AB325996

Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 12 bands)

SDS-PAGE - Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 12 bands) (AB325996)

  • 0
  • 0
Proteins & Peptides

AB101091

Recombinant Human PITPNB protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human PITPNB protein (His tag N-Terminus) (AB101091)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Secondary Antibodies

AB150121

Goat Anti-Mouse IgM mu chain (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgM mu chain (Alexa Fluor® 488) (AB150121)

  • 5
  • 5
Secondary Antibodies

AB99695

Mouse monoclonal [SB62a] Anti-Rabbit IgG light chain

  • 0
  • 0

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