JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB201877

重组人PGM2蛋白

Recombinant Human PGM2 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human PGM2 protein is a Human Full Length protein, in the 1 to 612 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

查看别名

MSTP006, PGM2, Phosphopentomutase, Glucose phosphomutase 2, Phosphodeoxyribomutase, Phosphoglucomutase-2

1 Images
SDS-PAGE - Recombinant Human PGM2 protein (AB201877)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PGM2 protein (AB201877)

15% SDS Page analysis of ab201877 (3μg).

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q96G03

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAAPEGSGLGEDARLDQETAQWLRWDKNSLTLEAVKRLIAEGNKEELRKCFGARMEFGTAGLRAAMGPGISRMNDLTIIQTTQGFCRYLEKQFSDLKQKGIVISFDARAHPSSGGSSRRFARLAATTFISQGIPVYLFSDITPTPFVPFTVSHLKLCAGIMITASHNPKQDNGYKVYWDNGAQIISPHDKGISQAIEENLEPWPQAWDDSLIDSSPLLHNPSASINNDYFEDLKKYCFHRSVNRETKVKFVHTSVHGVGHSFVQSAFKAFDLVPPEAVPEQKDPDPEFPTVKYPNPEEGKGVLTLSFALADKTKARIVLANDPDADRLAVAEKQDSGEWRVFSGNELGALLGWWLFTSWKEKNQDRSALKDTYMLSSTVSSKILRAIALKEGFHFEETLTGFKWMGNRAKQLIDQGKTVLFAFEEAIGYMCCPFVLDKDGVSAAVISAELASFLATKNLSLSQQLKAIYVEYGYHITKASYFICHDQETIKKLFENLRNYDGKNNYPKACGKFEISAIRDLTTGYDDSQPDKKAVLPTSKSSQMITFTFANGGVATMRTSGTEPKIKYYAELCAPPGNSDPEQLKKELNELVSAIEEHFFQPQKYNLQPKAD","proteinLength":"Full Length","predictedMolecularWeight":"70.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":612,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q96G03","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Phosphoglucomutase 2 also known as PGM2 is an enzyme involved in carbohydrate metabolism. It catalyzes the reversible conversion of glucose-1-phosphate to glucose-6-phosphate an essential step in glycogenesis and glycogenolysis. PGM2 has a mass of about 65 kDa and is expressed in various tissues including liver muscle and brain. It is often expressed in cells that require significant amounts of energy due to its role in glucose utilization.
Biological function summary

PGM2 functions to maintain cellular energy balance by supporting glycogen storage and breakdown. It operates as an individual enzyme not being part of any multi-enzyme complex but it significantly impacts glucose flux within cells. The enzyme plays a role in both anabolic and catabolic processes highlighting its importance in energy homeostasis. Adequate functioning of PGM2 ensures that cells have access to glucose during fasting or between meals vital for processes like muscle contraction and brain function.

Pathways

PGM2 is actively involved in the glycogen metabolism pathway and interacts with key enzymes like glycogen phosphorylase and glycogen synthase. Its enzymatic activity links it to pathways such as glycolysis where glucose-6-phosphate serves as a substrate. Through its role in glucose conversion PGM2 influences the availability of substrate for additional enzymes in glycolysis and glycogenesis impacting energy production and storage in cells.

Defects in PGM2 have been associated with glycogen storage disease which affects glucose and glycogen metabolism leading to energy production issues. It is also observed in metabolic myopathies where disordered energy metabolism leads to muscle weakness and fatigue. PGM2 interacts with glycogen phosphorylase in these disorders as both play parts in the conversion of glucose-1-phosphate to glucose-6-phosphate implicating their coordination in maintaining metabolic stability.

特殊说明

形式

Liquid

附加说明

purified by using conventional chromatography techniques

常规信息

功能

Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses (PubMed : 17804405). Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate but with a lower catalytic efficiency (PubMed : 17804405). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (PubMed : 17804405). In vitro, has also a low glucose 1,6-bisphosphate synthase activity which is most probably not physiologically relevant (PubMed : 17804405, PubMed : 18927083).

序列相似性

Belongs to the phosphohexose mutase family.

产品实验方案

靶点信息

Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses (PubMed : 17804405). Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate but with a lower catalytic efficiency (PubMed : 17804405). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (PubMed : 17804405). In vitro, has also a low glucose 1,6-bisphosphate synthase activity which is most probably not physiologically relevant (PubMed : 17804405, PubMed : 18927083).
See full target information PGM2

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂,为您科研的每一步提供支持。若我们的产品未能达到预期性能,我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com