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AB167869

重组人PEX26蛋白

Recombinant Human PEX26 protein

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Recombinant Human PEX26 protein is a Human Fragment protein, in the 1 to 246 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

查看别名

Peroxisome assembly protein 26, Peroxin-26, PEX26

1 Images
SDS-PAGE - Recombinant Human PEX26 protein (AB167869)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PEX26 protein (AB167869)

15% SDS-PAGE analysis of 3µg ab167869.

关键信息

纯度

>90% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q7Z412

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris-HCl buffer, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMKSDSSTSAAPLRGLGGPLRSSEPVRAVPARAPAVDLLEEAADLLVVHLDFRAALETCERAWQSLANHAVAEEPAGTSLEVKCSLCVVGIQALAEMDRWQEVLSWVLQYYQVPEKLPPKVLELCILLYSKMQEPGAVLDVVGAWLQDPANQNLPEYGALAEFHVQRVLLPLGCLSEAEELVVGSAAFGEERRLDVLQAIHTARQQQKQEHSGSEEAQKPNLEGSVSHKFLSLPMLVRQLWDSAVSH","proteinLength":"Fragment","predictedMolecularWeight":"29.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":246,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q7Z412","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PEX26 also known as Peroxin 26 is a protein critical for peroxisomal function. It has a molecular mass of approximately 33 kDa. PEX26 is localized in the peroxisomal membrane and is mainly expressed in various tissues including liver kidney and brain. Its role is important in the peroxisome import machinery where it anchors the PEX1-PEX6 complex to the peroxisome membrane enabling the transport and maintenance of matrix proteins necessary for peroxisome function.
Biological function summary

The importance of PEX26 lies in its role as part of the peroxisome biogenesis complex. It anchors PEX1 and PEX6 which are essential components for ATPase activity important for peroxisome assembly and function. This tightly regulated process ensures that peroxisomes function correctly in metabolic pathways such as fatty acid β-oxidation and reactive oxygen species detoxification.

Pathways

PEX26 is instrumental in the peroxisomal matrix protein import pathway. This pathway includes the interaction between PEX1 and PEX6 where PEX26 is an anchor within the membrane structure. The pathway's proper function is essential to cellular lipid metabolism and detoxification processes linking it to proteins such as PEX5 that acts as a receptor for matrix proteins targeting peroxisomes.

Defects in PEX26 often associate with peroxisome biogenesis disorders such as Zellweger Spectrum Disorders (ZSD). These disorders result from improper peroxisome function due to mutations in the PEX26 gene leading to various metabolic dysfunctions. PEX26 mutations are especially significant in Zellweger syndrome a severe form of ZSD. The inability to correctly bind PEX1 and PEX6 leads to defective peroxisomal assembly critically impacting cellular health and leading to clinical manifestations associated with these disorders.
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特殊说明

形式

Liquid

附加说明

ab167869 was purified using conventional chromatography techniques.

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常规信息

功能

Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes (PubMed : 12717447, PubMed : 12851857, PubMed : 16257970, PubMed : 16763195, PubMed : 16854980, PubMed : 21362118). PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane (PubMed : 12717447, PubMed : 12851857, PubMed : 16257970, PubMed : 16763195, PubMed : 16854980, PubMed : 21362118).

序列相似性

Belongs to the peroxin-26 family.

亚细胞定位

Peroxisome membrane

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产品实验方案

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靶点信息

Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes (PubMed : 12717447, PubMed : 12851857, PubMed : 16257970, PubMed : 16763195, PubMed : 16854980, PubMed : 21362118). PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane (PubMed : 12717447, PubMed : 12851857, PubMed : 16257970, PubMed : 16763195, PubMed : 16854980, PubMed : 21362118).
See full target information PEX26
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