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重组人PDE8A蛋白(ab114643)

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SDS-PAGE - Recombinant Human PDE8A protein (ab114643)

    Key features and details

    • Expression system: Wheat germ
    • Suitable for: ELISA, SDS-PAGE, WB

    描述

    • 产品名称

      重组人PDE8A蛋白

    • 表达系统

      Wheat germ

    • Accession

      O60658

    • 蛋白长度

      Protein fragment

    • 无动物成分

      No

    • 性质

      Recombinant

      • 种属

        Human

      • 序列

        RLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQ VLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFL

      • 预测分子量

        36 kDa including tags

      • 氨基酸

        32 to 121

    技术指标

    Our Abpromise guarantee covers the use of ab114643 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • 应用

      ELISA

      SDS-PAGE

      Western blot

    • 形式

      Liquid
    • Concentration information loading...

    制备和贮存

    • 稳定性和存储

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.3% Glutathione, 0.79% Tris HCl

    常规信息

    • 别名

      • 5''-cyclic phosphodiesterase 8A
      • cAMP specific cyclic nucleotide phosphodiesterase 8A
      • FLJ16150
      • High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A
      • High affinity cAMP-specific and IBMX-insensitive 3''
      • HsT19550
      • PDE 8A
      • PDE8A
      • PDE8A_HUMAN
      • Phosphodiesterase 8A
      • Phosphodiesterase8A
      • Weakly similar to 3'5' cyclic nucleotide phosphodiesterase
      see all

    • 功能

      Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

    • 组织特异性

      Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.

    • 通路

      Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

    • 序列相似性

      Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
      Contains 1 PAC (PAS-associated C-terminal) domain.
      Contains 1 PAS (PER-ARNT-SIM) domain.

    • 结构域

      Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
    • Information by UniProt

    图片

    • SDS-PAGE - Recombinant Human PDE8A protein (ab114643)
      SDS-PAGE - Recombinant Human PDE8A protein (ab114643)
      12.5% SDS-PAGE image showing ab114643 Stained with Coomassie Blue.

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (0)

    发表研究结果有使用 ab114643？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab114643 尚未被引用在任何文献中。

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