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AB179959

重组人PCTAIRE3蛋白

Recombinant Human PCTAIRE3 protein

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Recombinant Human PCTAIRE3 protein is a Human Full Length protein, in the 1 to 472 aa range, expressed in Baculovirus infected Sf9 cells, with >75%, suitable for SDS-PAGE, WB.

查看别名

PCTAIRE3, PCTK3, CDK18, Cyclin-dependent kinase 18, Cell division protein kinase 18, PCTAIRE-motif protein kinase 3, Serine/threonine-protein kinase PCTAIRE-3

1 Images
SDS-PAGE - Recombinant Human PCTAIRE3 protein (AB179959)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PCTAIRE3 protein (AB179959)

SDS-PAGE analysis of ab179959.

关键信息

纯度

>75% Densitometry

表达系统

Baculovirus infected Sf9 cells

标签

GST tag N-Terminus

应用

WB, SDS-PAGE

applications

生物活性

No

访问

Q07002

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF","proteinLength":"Full Length","predictedMolecularWeight":"76 kDa","actualMolecularWeight":null,"aminoAcidEnd":472,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q07002","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PCTAIRE3 also known as cyclin-dependent kinase 18 (CDK18) is a serine/threonine protein kinase. It has a molecular mass of approximately 37 kDa. Typically this protein is found in high amounts in the testis brain and pancreas. PCTAIRE3 plays a role in cellular processes by acting as a regulatory kinase. It is involved in phosphorylating specific substrates which is important for its function.
Biological function summary

PCTAIRE3 contributes to cell cycle regulation and neuronal signaling. It is a part of the cyclin-dependent kinase (CDK) family which is responsible for controlling progression through the cell cycle. These kinases often form complexes with cyclins to perform their regulatory roles effectively. The protein's expression in neuronal tissues suggests a role in synaptic plasticity or neuronal development though exact mechanisms need further study.

Pathways

PCTAIRE3 participates in the cell cycle and signal transduction pathways. It interacts with other CDKs and cyclins to help coordinate the cell cycle particularly in the G2/M transition. PCTAIRE3's involvement with these pathways links it to proteins like cyclin B and CDK1. Additionally its presence in signal transduction pathways connects it to various molecular signals which influence cellular responses and decisions.

Mutations or dysregulation of PCTAIRE3 have been implicated in cancers and neurodevelopmental disorders. In cancer aberrant expression of CDKs can lead to uncontrolled cell proliferation. PCTAIRE3 has been associated with specific tumors where it may interact with proteins like p53 that are critical in controlling the cell cycle and tumor suppression. In neurodevelopmental disorders variations in PCTAIRE3 might influence synaptic signaling contributing to conditions such as schizophrenia though research on these connections remains ongoing.
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特殊说明

形式

Liquid

附加说明

Affinity purified.

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常规信息

功能

May play a role in signal transduction cascades in terminally differentiated cells.

序列相似性

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

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产品实验方案

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靶点信息

May play a role in signal transduction cascades in terminally differentiated cells.
See full target information CDK18
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搭配使用产品

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Secondary Antibodies

AB191866

VHH Single Domain Anti-Rabbit IgG Fc (HRP)

Recombinant

Western blot - VHH Single Domain Anti-Rabbit IgG Fc (HRP) (AB191866)

  • 5
  • 2
Primary Antibodies

AB154557

Anti-PCTAIRE3 antibody

Western blot - Anti-PCTAIRE3 antibody (AB154557)

  • 0
  • 0
Proteins & Peptides

AB259412

Recombinant human VEGF 165A protein (Active)

Premium Bioactive

Mass Spectrometry - Recombinant human VEGF 165A protein (Active) (AB259412)

  • 0
  • 0

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