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AB171496

重组人 PAX9 蛋白 (denatured) (His tag N-Terminus)

Recombinant Human PAX9 protein (denatured) (His tag N-Terminus)

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Recombinant Human PAX9 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 341 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

查看别名

Paired box protein Pax-9, PAX9

1 Images
SDS-PAGE - Recombinant Human PAX9 protein (denatured) (His tag N-Terminus) (AB171496)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PAX9 protein (denatured) (His tag N-Terminus) (AB171496)

15% SDS-PAGE analysis of ab171496 (3μg).

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

P55771

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMEPAFGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGNLAQQGHYDSYKQHQPTPQPALPYNHIYSYPSPITAAAAKVPTPPGVPAIPGSVAMPRTWPSSHSVTDILGIRSITDQVSDSSPYHSPKVEEWSSLGRNNFPAAAPHAVNGLEKGALEQEAKYGQAPNGLPAVGSFVSASSMAPYPTPAQVSPYMTYSAAPSGYVAGHGWQHAGGTSLSPHNCDIPASLAFKGMQAAREGSHSVTASAL","proteinLength":"Full Length","predictedMolecularWeight":"38.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":341,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P55771","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PAX9 also known as paired box gene 9 is a transcription factor with a molecular mass of approximately 37 kDa. It belongs to the PAX family of proteins characterized by the presence of a paired box domain. Mechanically PAX9 plays a role in DNA binding and transcriptional regulation of target genes. It is expressed in developing teeth craniofacial regions limbs and parts of the neural crest. This expression pattern highlights PAX9’s involvement in early developmental processes.
Biological function summary

PAX9 contributes significantly to developmental patterning and organogenesis. It functions as a part of a transcription factor complex that coordinates the gene networks necessary for these processes. PAX9 interacts with other PAX family members and developmental regulators mediating the formation of structures such as teeth and skeletal elements. PAX9’s role in these processes ensures proper structural differentiation and morphogenesis during development.

Pathways

PAX9 plays an important role in the tooth development pathway and the Wnt signaling pathway. During tooth development it interacts with proteins like MSX1 and BMP4 guiding tooth patterning and morphogenesis. In the Wnt pathway PAX9 influences cell signaling pivotal for cell fate determination and embryonic development where it cooperates with Wnt proteins to modulate pathway-specific gene expression.

Mutations or dysregulation of PAX9 have been associated with conditions such as tooth agenesis and oral clefts. Tooth agenesis which involves missing teeth arises from disruptions in PAX9’s functionality during tooth development often involving MSX1 as well. Oral clefts such as cleft lip and palate also involve PAX9 interactions during craniofacial development. These associations emphasize PAX9's critical role in maintaining normal developmental functions and its impact on congenital anomalies.
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特殊说明

形式

Liquid

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常规信息

功能

Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.
See full target information PAX9
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搭配使用产品

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SDS-PAGE - Recombinant Human PRX-1 protein (His tag N-Terminus) (AB171502)

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Proteins & Peptides

AB171691

Recombinant Human UQCRQ protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human UQCRQ protein (denatured) (His tag N-Terminus) (AB171691)

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Proteins & Peptides

AB186985

Recombinant Human UPRT protein (Tagged-His Tag)

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Primary Antibodies

AB28538

Anti-PAX9 antibody [7C2]

Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-PAX9 antibody [7C2] (AB28538)

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