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AB130016

重组人OVCA2蛋白

Recombinant Human OVCA2 protein

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Recombinant Human OVCA2 protein is a Human Full Length protein, in the 1 to 227 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

查看别名

Esterase OVCA2, Ovarian cancer-associated gene 2 protein, OVCA2

1 Images
SDS-PAGE - Recombinant Human OVCA2 protein (AB130016)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human OVCA2 protein (AB130016)

15% SDS-PAGE analysis of ab130016 (3 μg).

关键信息

纯度

>90% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q8WZ82

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMAAQRPLRVLCLAGFRQSERGFREKTGALRKALRGRAELVCLSGPHPVPDPPGPEGARSDFGSCPPEEQPRGWWFSEQEADVFSALEEPAVCRGLEESLGMVAQALNRLGPFDGLLGFSQGAALAALVCALGQAGDPRFPLPRFILLVSGFCPRGIGFKESILQRPLSLPSLHVFGDTDKVIPSQESVQLASQFPGAITLTHSGGHFIPAAAPQRQAYLKFLDQFAE","proteinLength":"Full Length","predictedMolecularWeight":"26.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":227,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WZ82","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

OVCA2 is also known as Ovarian Carcinoma Amplified Transcript 2 or OVCA 2. This protein has a molecular mass of approximately 28 kDa. It is expressed mainly in the ovary as well as the heart placenta liver and to a lesser extent in the lung and pancreas. Mechanically OVCA2 protein functions as a potential prolyl isomerase suggesting an involvement in protein folding process which impacts stability and function of its substrates.
Biological function summary

OVCA2 impacts cellular processes by modulating protein dynamics and stability. Through its isomerase activity it contributes to proper protein folding and maintenance. It participates in cellular stress response by ensuring proteins maintain their correct conformation under changing conditions. There is limited evidence that OVCA2 functions alone and it may interact with other molecular chaperones or be part of a protein complex although this is not definitively established yet.

Pathways

OVCA2 is likely involved in protein quality control mechanisms essential for cellular homeostasis. It intersects with the protein folding and ubiquitin-proteasome pathways which are critical for managing improperly folded proteins. Related proteins such as FKBP4 and cyclophilins might operate along with OVCA2 to regulate protein folding and degradation although specific interaction pathways still require further elucidation.

OVCA2 has associations with certain cancers notably ovarian carcinoma. Aberrant expression or mutations might impact the protein's ability to maintain proper protein folding potentially contributing to tumorigenesis. Connections with proteins like p53 which is involved in cancer pathways suggest that OVCA2's dysfunction could have roles in impaired regulatory pathways leading to cancer development. Further research is necessary to clarify these relationships more thoroughly.

特殊说明

形式

Liquid

附加说明

ab130016 is purified using conventional chromatography techniques.

常规信息

序列相似性

Belongs to the LovG family.

翻译后修饰

Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL-60.

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

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