重组人 OPRT 蛋白 (His tag C-Terminus)
Recombinant Human OPRT protein (His tag C-Terminus)
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Recombinant Human OPRT protein (His tag C-Terminus) is a Human Full Length protein, in the 1 to 480 aa range, expressed in Baculovirus infected insect cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
查看别名
OK/SW-cl.21, UMPS, Uridine 5'-monophosphate synthase, UMP synthase
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human OPRT protein (His tag C-Terminus) (AB226883)
15% SDS-PAGE analysis of 3 μg ab226883.
MW : 50-70 kDa (SDS-PAGE under reducing conditions).
搭配使用产品
反应性数据
产品详情
序列信息
性能和储存信息
形式
纯化工艺
运输条件
推荐的短期储存时间
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Orotate phosphoribosyltransferase contributes to the de novo synthesis of pyrimidine nucleotides which are essential components of DNA and RNA. OPRT operates as part of the UMP biosynthesis via the de novo pathway forming a complex with orotidine-5'-phosphate decarboxylase in some organisms. This linkage enhances efficiency in pyrimidine nucleotide production reflecting its central role in cell growth and division.
Pathways
The protein integrates into the pyrimidine metabolism pathway. It interacts closely with orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase forming dual-function enzymes that streamline UMP synthesis. OPRT’s activity ties it to key metabolic cycles including nucleotide salvage pathways thereby establishing critical links across metabolic networks essential for nucleic acid production.
常规信息
功能
Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP).
序列相似性
In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.. In the C-terminal section; belongs to the OMP decarboxylase family.
靶点信息
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