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AB123209

重组人NXT2蛋白

Recombinant Human NXT2 protein

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Recombinant Human NXT2 protein is a Human Full Length protein, in the 1 to 197 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

查看别名

BM-025, DC9, NXT2, NTF2-related export protein 2, Protein p15-2

1 Images
SDS-PAGE - Recombinant Human NXT2 protein (AB123209)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human NXT2 protein (AB123209)

15% SDS-PAGE analysis of ab123209 (3μg).

关键信息

纯度

>95% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q9NPJ8

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 40% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMRKYRSHWSQGDREGYQRRSNYYEGPHTSHSSPADRTREEVVTPTLPEHTATRSQMATSLDFKTYVDQACRAAEEFVNIYYETMDKRRRALTRLYLDKATLIWNGNAVSGLDALNNFFDTLPSSEFQVNMLDCQPVHEQATQSQTTVLVVTSGTVKFDGNKQHFFNQNFLLTAQSTPNNTVWKIASDCFRFQDWSSS","proteinLength":"Full Length","predictedMolecularWeight":"25.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":197,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NPJ8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

NXT2 also known as NTF2-like export factor 2 plays a role in nuclear transport. This protein has a molecular mass of approximately 14 kDa. It is expressed in a variety of tissues primarily in the nucleus where it functions in the export of RNA from the nucleus to the cytoplasm. The protein's mechanical action facilitates the translocation of mRNA and tRNA substrates across the nuclear envelope an essential step in gene expression regulation.
Biological function summary

NXT2 is involved in the transport machinery where it associates with nuclear export complexes. It interacts with other proteins like NXF1 to function as a part of the mRNA export pathway. The presence of NXT2 in these export complexes highlights its necessity in post-transcriptional regulation. This role emphasizes its significance in maintaining cellular function by ensuring that mRNA is correctly moved to the cytoplasm for translation.

Pathways

NXT2 has essential roles in the mRNA nuclear export pathway and is also linked to the tRNA export pathway. These pathways are important for proper gene expression and protein synthesis. NXT2 interacts closely with proteins such as NXF1 and other nucleoporins acting as an important component in these pathways. Its role in these processes hints at its broader implications in cellular signaling and adaptation directly influencing how cells respond to environmental and developmental cues.

Alterations in NXT2 function can relate to cancer and neurodegenerative disorders. Abnormal NXT2 activity may disrupt RNA export leading to uncontrolled cell growth or impaired neuronal function. NXT2's relationship with proteins involved in these diseases such as NXF1 in the case of cancer highlights its importance in disease pathology. These connections point to NXT2 as a potential target for therapeutic intervention opening avenues for more precise treatment strategies.
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特殊说明

形式

Liquid

附加说明

ab123209 is purified using conventional chromatography techniques.

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常规信息

功能

Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.
See full target information NXT2
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Complementary Products

Primary Antibodies

AB121797

Anti-NXT2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NXT2 antibody (AB121797)

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