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AB107153

重组人 NUDT9 蛋白 (His tag N-Terminus)

Recombinant Human NUDT9 protein (His tag N-Terminus)

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Recombinant Human NUDT9 protein (His tag N-Terminus) is a Human Full Length protein, in the 47 to 350 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

查看别名

NUDT10, PSEC0099, UNQ3012/PRO9771, NUDT9, ADP-ribose diphosphatase, ADP-ribose phosphohydrolase, Adenosine diphosphoribose pyrophosphatase, Nucleoside diphosphate-linked moiety X motif 9, ADPR-PPase, Nudix motif 9

1 Images
SDS-PAGE - Recombinant Human NUDT9 protein (AB107153)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human NUDT9 protein (AB107153)

15% SDS-PAGE showing ab107153 (3μg).
Note : Molecular weight on SDS-PAGE will appear higher.

关键信息

纯度

>95% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

Mass Spec, SDS-PAGE

applications

生物活性

No

访问

Q9BW91

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMNTNVMSGSNGSKENSHNKARTSPYPGSKVERSQVPNEKVGWLVEWQDYKPVEYTAVSVLAGPRWADPQISESNFSPKFNEKDGHVERKSKNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPIITRWKRDSSGNKIMHPVSGKHILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEEALNSLQKTSAEKREIEEKLHKLFSQDHLVIYKGYVDDPRNTDNAWMETEAVNYHDETGEIMDNLMLEAGDDAGKVKWVDINDKLKLYASHSQFIKLVAEKRDAHWSEDSEADCHAL","proteinLength":"Full Length","predictedMolecularWeight":"36.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":350,"aminoAcidStart":47,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BW91","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

NUDT9 also known as Nudix Hydrolase 9 is an enzyme that exhibits pyrophosphatase activity on molecules like ADP-ribose. It has an approximate mass of 35 kDa. NUDT9 is expressed in various tissues with significant levels observed in the brain and heart. This protein helps break down ADP-ribose into AMP and ribose-5-phosphate assisting in the regulation of cellular ADP-ribose concentrations.
Biological function summary

NUDT9 helps to maintain cellular balance by controlling levels of ADP-ribose a substrate for poly ADP-ribose polymerases. This regulation is essential for energy metabolism and DNA repair processes. NUDT9 operates independently and does not blend into larger protein complexes focusing strictly on its enzymatic role ensuring the cell's homeostasis.

Pathways

NUDT9 is significantly involved in NAD+ metabolism and the DNA repair mechanism. By converting ADP-ribose NUDT9 interacts with pathways that are central to maintaining cellular energy balance and protecting cells from DNA damage. It is functionally linked with enzymes such as PARP (poly ADP-ribose polymerase) which are pivotal in detecting and signaling DNA strand breaks.

NUDT9's role in regulating ADP-ribose links it to conditions where cellular stress and energy metabolism are disrupted. Its malfunction has correlations with neurodegenerative diseases like Alzheimer's where altered energy metabolism and DNA damage responses are critical factors. NUDT9 also connects with proteins like PARP which are implicated in this pathological context indicating a potential therapeutic target for managing such disorders.
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特殊说明

形式

Liquid

附加说明

ab107153 is purified using conventional chromatography techniques.

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常规信息

功能

Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.

序列相似性

Belongs to the Nudix hydrolase family. NudF subfamily.

亚细胞定位

Mitochondrion

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产品实验方案

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靶点信息

Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
See full target information NUDT9
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搭配使用产品

Proteins & Peptides

AB103059

Recombinant Human NUDT16 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human NUDT16 protein (AB103059)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB197021

Anti-NUDT9 antibody [EPR15175]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-NUDT9 antibody [EPR15175] (AB197021)

  • 0
  • 0
Secondary Antibodies

AB150191

Rabbit Anti-Human IgM mu chain (Alexa Fluor® 647)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Rabbit Anti-Human IgM mu chain (Alexa Fluor® 647) (AB150191)

  • 0
  • 0

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