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AB132326

重组人NUCB1蛋白

Recombinant Human NUCB1 protein

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Recombinant Human NUCB1 protein is a Human Full Length protein, in the 28 to 461 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

查看别名

NUC, NUCB1, Nucleobindin-1, CALNUC

1 Images
SDS-PAGE - Recombinant Human NUCB1 protein (AB132326)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human NUCB1 protein (AB132326)

12.5% SDS-PAGE analysis of ab132326 stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

ELISA, SDS-PAGE, WB

applications

生物活性

No

访问

Q02818

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"PLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELERQEVSRPRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHPDTDDVPVPAPAGDQKEVDTSEKKLLERLPEVEVPQHL","proteinLength":"Full Length","predictedMolecularWeight":"73.48 kDa","actualMolecularWeight":null,"aminoAcidEnd":461,"aminoAcidStart":28,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q02818","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The protein NUCB1 also known as Nucleobindin-1 functions mechanically as a calcium-binding protein. It has approximately a mass of 55 kDa and belongs to a group of calcium-binding proteins containing EF-hand motifs. NUCB1 expresses in a variety of tissues notably the nervous system and endocrine tissues. The protein comprises several functional domains including a signal peptide helix-loop-helix motif and nuclear localization signal.
Biological function summary

NUCB1 participates in the regulation of cellular calcium homeostasis and signaling pathways. It is not a part of a multi-protein complex but it acts as a molecular chaperone influencing the stability and function of other proteins within the cell. NUCB1 also plays a role in secretory pathways within the cell which is relevant to its expression in endocrine tissues. Its regulatory functions in calcium signaling are critical for cellular activities such as secretion and cell division.

Pathways

NUCB1 interacts with cellular signaling mechanisms particularly those related to intracellular calcium dynamics. It is involved in pathways like the calcium signaling pathway and the insulin signaling pathway. Within these pathways NUCB1 associates with proteins such as calmodulin which also binds calcium and contributes to signal transduction. The protein modulates activities within these pathways affecting how cells respond to external signals.

NUCB1 exhibits associations with certain conditions linked to disturbed calcium regulation. One such disorder is Alzheimer's disease where alterations in calcium signaling play a role in disease progression. The protein furthermore relates to type 2 diabetes involving its role in the insulin signaling pathway. In these contexts NUCB1 connects to other proteins such as amyloid precursor protein in Alzheimer's disease highlighting disruptions in calcium homeostasis mechanisms.
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特殊说明

形式

Liquid

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常规信息

功能

Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity).

序列相似性

Belongs to the nucleobindin family.

翻译后修饰

O-glycosylated.

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产品实验方案

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靶点信息

Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity).
See full target information NUCB1
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搭配使用产品

Proteins & Peptides

AB132133

Recombinant Human Thymosin beta 10 protein

SDS-PAGE - Recombinant Human Thymosin beta 10 protein (AB132133)

  • 0
  • 0
Primary Antibodies

AB154262

Anti-NUCB1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-NUCB1 antibody (AB154262)

  • 5
  • 1
Cell Lines & Lysates

AB266299

Human NUCB1 knockout HEK-293T cell line

Sanger Sequencing - Human NUCB1 knockout HEK-293T cell line (AB266299)

  • 0
  • 0
Primary Antibodies

AB230522

Anti-CASC4 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CASC4 antibody - C-terminal (AB230522)

  • 0
  • 0

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