重组人NRG4蛋白(ab174432)
Key features and details
- Expression system: Escherichia coli
- Purity: > 90% SDS-PAGE
- Tags: His tag N-Terminus
- Suitable for: SDS-PAGE, MS
描述
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产品名称
重组人NRG4蛋白 -
纯度
> 90 % SDS-PAGE.
ab174432 is purified by conventional chromatography techniques. -
表达系统
Escherichia coli -
Accession
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蛋白长度
Full length protein -
无动物成分
No -
性质
Recombinant -
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种属
Human -
序列
MGSSHHHHHH SSGLVPRGSH MGSMPTDHEE PCGPSHKSFC LNGGLCYVIP TIPSPFCRCV ENYTGARCEE VFLPGSSIQT KSNL -
预测分子量
9 kDa including tags -
氨基酸
1 to 61 -
标签
His tag N-Terminus -
额外的序列信息
NCBI Accession No. NP_612640
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab174432 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
Mass Spectrometry
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质谱法
MALDI-TOF -
形式
Liquid -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 0.32% Tris HCl, 30% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.02% DTT
常规信息
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别名
- DKFZp779N0541
- DKFZp779N1944
- Heregulin 4
see all -
功能
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. -
序列相似性
Belongs to the neuregulin family.
Contains 1 EGF-like domain. -
结构域
The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization.
ERBB receptor binding is elicited entirely by the EGF-like domain. -
翻译后修饰
Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
Extensive glycosylation precedes the proteolytic cleavage. -
细胞定位
Secreted and Cell membrane. Does not seem to be active. - Information by UniProt
图片
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SDS-PAGE - Recombinant Human NRG4 protein (ab174432)
15% SDS-PAGE analysis of ab174432 (3 μg).
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab174432 尚未被引用在任何文献中。