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AB171677

重组人NOB1蛋白(denatured)

Recombinant Human NOB1 protein (denatured)

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Recombinant Human NOB1 protein (denatured) is a Human Full Length protein, in the 1 to 412 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.

查看别名

ART4, NOB1P, PSMD8BP1, MSTP158, NOB1, RNA-binding protein NOB1, Phosphorylation regulatory protein HP-10, Protein ART-4

1 Images
SDS-PAGE - Recombinant Human NOB1 protein (denatured) (AB171677)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human NOB1 protein (denatured) (AB171677)

15% SDS-PAGE analysis of ab171677 (3µg).

关键信息

纯度

>80% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q9ULX3

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAPVEHVVADAGAFLRHAALQDIGKNIYTIREVVTEIRDKATRRRLAVLPYELRFKEPLPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPQKVKVSSSIQHPETPLHISGFHLPYKPKPPQETEKGHSACEPENLEFSSFMFWRNPLPNIDHELQELLIDRGEDVPSEEEEEEENGFEDRKDDSDDDGGGWITPSNIKQIQQELEQCDVPEDVRVGCLTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCSHCGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSQKARQKTNVFAPDYIAGVSPFVENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR","proteinLength":"Full Length","predictedMolecularWeight":"49.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":412,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9ULX3","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Nucleolar protein 1 (NOB1) plays an important role in ribosomal RNA processing and biogenesis. Often referred to as NOB1p it is a protein that weighs approximately 55 kDa. NOB1 is expressed mainly in the nucleolus. This protein contains several domains such as the PIN domain which is important in its RNA cleavage function.
Biological function summary

NOB1 functions as a part of a complex called the 26S proteasome regulatory complex. It participates in the maturation of the 20S proteasome facilitating the processing of 18S rRNA which is important for ribosome assembly. This role highlights its importance for maintaining ribosomal function and protein synthesis.

Pathways

NOB1's role in ribosome assembly ties it to the ribosome biogenesis and protein synthesis pathways. It works closely with proteins such as PNO1 and the 18S rRNA processing machinery. These interactions ensure that ribosomes are properly assembled and functional which is critical for cellular growth and division.

Mutations or dysregulation of NOB1 have implications in cancer development. Aberrant expression of NOB1 has been linked to tumorigenesis particularly in pathways involving the oncogenic protein MYC. By influencing ribosome biogenesis NOB1 can contribute to the uncontrolled proliferation characteristic of cancer cells.
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特殊说明

形式

Liquid

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常规信息

功能

May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).

序列相似性

Belongs to the NOB1 family.

亚细胞定位

Nucleus

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).
See full target information NOB1
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