AB116955

重组人 NELL1 蛋白 (GST tag N-Terminus)

Name: 重组人NELL1蛋白 (ab116955)| Abcam中文官网
Brand: Abcam Limited
SKU: AB116955
Price: 6621 CNY
Availability: InStock

Recombinant Human NELL1 protein (GST tag N-Terminus)

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Recombinant Human NELL1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 810 aa range, expressed in Wheat germ, suitable for SDS-PAGE, WB.

查看别名

NRP1, NELL1, Protein kinase C-binding protein NELL1, NEL-like protein 1, Nel-related protein 1

1 Images

SDS-PAGE - Recombinant Human NELL1 protein (GST tag N-Terminus) (AB116955)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human NELL1 protein (GST tag N-Terminus) (AB116955)

12.5% SDS-PAGE showing ab116955 at approximately 115.17kDa stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

应用

WB, SDS-PAGE

applications

生物活性

访问

Q92832

不含动物源

不含载体蛋白

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>Recombinant protein.</p>" } } }

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序列信息

[{"sequence":"MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQNN","proteinLength":"Full Length","predictedMolecularWeight":"115.17 kDa","actualMolecularWeight":null,"aminoAcidEnd":810,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q92832","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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性能和储存信息

运输条件

Dry Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

False

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

NELL1 also known as Neural EGFL Like 1 is a protein primarily involved in cell signaling processes. Its molecular weight is approximately 87 kDa. NELL1 expresses in tissues such as bone cartilage blood vessels and the nervous system. It functions as a secreted glycoprotein and may play a role in mediating cellular communication.

Biological function summary

This protein influences cell growth differentiation and apoptosis. NELL1 is not known to be part of a multiprotein complex but it interacts with various factors that regulate tissue development. It has significant functions in osteogenesis and angiogenesis impacting bone formation and blood vessel formation. The presence of NELL1 is essential for normal skeletal development and repair.

Pathways

Multiple molecular interactions involve NELL1 in critical signaling pathways. NELL1 acts in the BMP signaling pathway an important player in bone and cartilage development. It also interacts with TGF-beta signaling pathways which regulate cell proliferation and differentiation. These interactions link NELL1 to proteins like BMP2 and TGF-beta receptors highlighting its role in cellular signaling dynamics.

NELL1 has associations with conditions like craniosynostosis and osteoporosis. Altered expression of NELL1 contributes to the premature fusion of skull bones in craniosynostosis. In osteoporosis NELL1 influences bone density and structure abnormalities. NELL1 also interacts with proteins such as RUNX2 which further contribute to the pathogenesis of these skeletal disorders.

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特殊说明

形式

Liquid

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常规信息

功能

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.

亚细胞定位

Nucleus envelope

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.

See full target information NELL1

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重组人 NELL1 蛋白 (GST tag N-Terminus)

Recombinant Human NELL1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human NELL1 protein (GST tag N-Terminus) (AB116955)

关键信息

表达系统

标签

应用

生物活性

访问

不含动物源

不含载体蛋白

种属

存储溶液