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AB153171

重组人MRPL3蛋白

Recombinant Human MRPL3 protein

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Recombinant Human MRPL3 protein is a Human Full Length protein, in the 1 to 348 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

MRL3, RPML3, MRPL3, Large ribosomal subunit protein uL3m, L3mt, MRP-L3

1 Images
SDS-PAGE - Recombinant Human MRPL3 protein (AB153171)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MRPL3 protein (AB153171)

ab153171 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, ELISA

applications

生物活性

No

访问

P09001

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

序列信息

[{"sequence":"MPGWRLLTQVGAQVLGRLGDGLGAALGPGNRTHIWLFVRGLHGKSGTWWDEHLSEENVPFIKQLVSDEDKAQLASKLCPLKDEPWPIHPWEPGSFRVGLIALKLGMMPLWTKDGQKHVVTLLQVQDCHVLKYTSKENCNGKMATLSVGGKTVSRFRKATSILEFYRELGLPPKQTVKIFNITDNAAIKPGTPLYAAHFRPGQYVDVTAKTIGKGFQGVMKRWGFKGQPATHGQTKTHRRPGAVATGDIGRVWPGTKMPGKMGNIYRTEYGLKVWRINTKHNIIYVNGSVPGHKNCLVKVKDSKLPAYKDLGKNLPFPTYFPDGDEEELPEDLYDENVCQPGAPSITFA","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":348,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P09001","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MRPL3 also known as Mitochondrial Ribosomal Protein L3 functions mechanically as a component of the mitochondrial ribosome specifically the large 39S subunit. This protein plays a role in mitochondrial protein synthesis. MRPL3 has a molecular mass of approximately 35 kDa. It is expressed in the mitochondria across various tissues having a pivotal involvement in the synthesis of proteins essential for mitochondrial energy generation.
Biological function summary

MRPL3 is important for the production of mitochondrial proteins by facilitating the translation of mitochondrial mRNA molecules. It forms part of the mitochondrial ribosome complex which is distinct from cytoplasmic ribosomes due to its protein-rich composition and specific ribosomal RNA components. This unique ribosome composition allows MRPL3 to contribute to mitochondrial-specific translational mechanisms that support cellular respiration and energy production.

Pathways

MRPL3 is notably involved in mitochondrial translation and oxidative phosphorylation pathways. In the context of oxidative phosphorylation MRPL3 works alongside other mitochondrial ribosomal proteins like MRPS23 to ensure the proper translation of essential components of the electron transport chain. This pathway is important for ATP production which cells use as an energy source. Efficient functioning of these pathways relies on proteins produced through the process that involves MRPL3.

MRPL3 is associated with mitochondrial diseases and certain forms of cancer due to its role in energy metabolism and protein synthesis. Mutations or dysregulation in MRPL3 may lead to mitochondrial dysfunction resulting in conditions such as mitochondrial cardiomyopathy. In some cancers MRPL3 expression levels can alter linked with changes in cellular energy demands and protein synthesis. The protein MRPL44 has shown to interact with MRPL3 suggesting a contribution to the pathology when mitochondrial protein synthesis is impaired.

特殊说明

形式

Liquid

常规信息

序列相似性

Belongs to the universal ribosomal protein uL3 family.

亚细胞定位

Mitochondrion

产品实验方案

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