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AB156342

重组人 MRPL1 蛋白 (His tag N-Terminus)

Recombinant Human MRPL1 protein (His tag N-Terminus)

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Recombinant Human MRPL1 protein (His tag N-Terminus) is a Human Full Length protein, in the 51 to 325 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.

查看别名

BM-022, MRPL1, Large ribosomal subunit protein uL1m, L1mt, MRP-L1

1 Images
SDS-PAGE - Recombinant Human MRPL1 protein (His tag N-Terminus) (AB156342)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MRPL1 protein (His tag N-Terminus) (AB156342)

15% SDS-PAGE analysis of 3µg ab156342.

关键信息

纯度

>80% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q9BYD6

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSKKTKKGAKEKTPDEKKDEIEKIKAYPYMEGEPEDDVYLKRLYPRQIYEVEKAVHLLKKFQILDFTSPKQSVYLDLTLDMALGKKKNVEPFTSVLSLPYPFASEINKVAVFTENASEVKIAEENGAAFAGGTSLIQKIWDDEIVADFYVAVPEIMPELNRLRKKLNKKYPKLSRNSIGRDIPKMLELFKNGHEIKVDEERENFLQTKIATLDMSSDQIAANLQAVINEVCRHRPLNLGPFVVRAFLRSSTSEGLLLKIDPLLPKEVKNEESEKEDA","proteinLength":"Full Length","predictedMolecularWeight":"33.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":325,"aminoAcidStart":51,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BYD6","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The MRPL1 protein also known as Mitochondrial Ribosomal Protein L1 is an essential component of the mitochondrial ribosome. It weighs approximately 34.1 kDa and plays a critical mechanical role in the synthesis of proteins within mitochondria. MRPL1 is expressed in various tissues with high metabolic activity particularly in the liver muscle and brain reflecting its importance in these energy-demanding areas.
Biological function summary

MRPL1 contributes to mitochondrial protein synthesis by being part of the mitochondrial large ribosomal subunit. It is one of the components that build the ribosome's structure enabling the translation of mitochondrial-encoded proteins. This integration into the ribosomal complex facilitates the accurate translation of mRNA which is necessary for proper mitochondrial function and energy production.

Pathways

MRPL1 functions in pathways related to mitochondrial translation and energy metabolism. It plays a part in the mitochondrial translation pathway a critical component for cellular energy production through oxidative phosphorylation. This pathway largely involves interactions with proteins such as MRPS22 which is part of the small subunit aiding in the synthesis of proteins important for the electron transport chain.

Altered MRPL1 function is associated with mitochondrial diseases and metabolic disorders. Mutations or defects in MRPL1 can lead to conditions like cardiomyopathy and MELAS syndrome (Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-like episodes). In these diseases the relationship between MRPL1 and the malfunctioning of mitochondrial-encoded proteins is evident and it interacts with other mRNAs translated in mitochondria impacting cellular energy balance.

特殊说明

形式

Liquid

附加说明

ab156342 is purified using conventional chromatography techniques.

常规信息

序列相似性

Belongs to the universal ribosomal protein uL1 family.

亚细胞定位

Mitochondrion

产品实验方案

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