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AB130051

重组人 MOG1 蛋白 (His tag N-Terminus)

Recombinant Human MOG1 protein (His tag N-Terminus)

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Recombinant Human MOG1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 186 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

查看别名

MOG1, RANGNRF, HSPC165, HSPC236, MDS5, RANGRF, Ran guanine nucleotide release factor, RanGNRF, Ran-binding protein MOG1

1 Images
SDS-PAGE - Recombinant Human MOG1 protein (His tag N-Terminus) (AB130051)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MOG1 protein (His tag N-Terminus) (AB130051)

SDS-PAGE analysis of ab130051 (3µg).

关键信息

纯度

>90% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

Mass Spec, SDS-PAGE

applications

生物活性

No

访问

Q9HD47

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSLENLALRGRCQEAWVLSGKQQIAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPPDNRSSLGPENLSPAPWSLGDFEQLVTSLTLHDPNIFGPQ","proteinLength":"Full Length","predictedMolecularWeight":"23 kDa","actualMolecularWeight":null,"aminoAcidEnd":186,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9HD47","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MOG1 also known as RanBP1-like protein MOG1 serves as an important regulator in the nuclear transport processes. This protein has a mass of approximately 25 kDa. MOG1 is expressed predominantly in brain tissue where it facilitates the movement of molecules between the nucleus and the cytoplasm. The presence of MOG1 in other tissues like the heart and skeletal muscle is also seen indicating its diverse expression profile in the human body.
Biological function summary

MOG1 interacts with the Ran GTPase system to mediate nuclear transport important for cellular function. MOG1 forms part of a complex that includes various nuclear import and export proteins. Its role extends to ensuring effective regulation of Ran GTPase activity maintaining the directionality of nuclear transport. This interaction allows MOG1 to influence cell cycle progression by regulating the transport of key regulatory proteins into the nucleus.

Pathways

MOG1 plays an essential role in the Ran GTPase signaling pathway. This pathway impacts the nuclear import and export processes contingent on the function of proteins such as Ran and importin-beta. MOG1 facilitates the conversion of Ran-GDP to Ran-GTP thereby enabling nuclear transport. Additionally it aligns with pathways involving protein import into the nucleus reflecting its comprehensive regulatory capacity over cellular transport mechanisms.

Mutations in MOG1 have been implicated in cardiac disorders particularly familial dilated cardiomyopathy. This condition occurs when MOG1's regulatory function on nuclear transport fails affecting heart function. In neurodegenerative diseases such as Alzheimer's altered expression of MOG1 may contribute to disease pathology by disrupting nuclear-cytoplasmic transport. The interaction between MOG1 and Ran GTPase becomes critical here as it influences overall protein distribution within cells impacting disease progression.
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特殊说明

形式

Liquid

附加说明

ab130051 was purified using conventional chromatography techniques.

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常规信息

功能

May regulate the intracellular trafficking of RAN (PubMed : 11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed : 29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed : 29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed : 18184654, PubMed : 21621375, PubMed : 23420830).

序列相似性

Belongs to the MOG1 family.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

May regulate the intracellular trafficking of RAN (PubMed : 11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed : 29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed : 29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed : 18184654, PubMed : 21621375, PubMed : 23420830).
See full target information RANGRF
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