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AB151354

重组人Miz1蛋白

Recombinant Human Miz1 protein

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Recombinant Human Miz1 protein is a Human Fragment protein, in the 1 to 188 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

查看别名

MIZ1, ZNF151, ZNF60, ZBTB17, Zinc finger and BTB domain-containing protein 17, Myc-interacting zinc finger protein 1, Zinc finger protein 151, Zinc finger protein 60, Miz-1

关键信息

纯度

>95% SDS-PAGE

内毒素水平

< 1 EU/µg

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q13105

不含动物源

No

不含载体蛋白

No

种属

Human

复溶

Reconstitute in PBS

存储溶液

pH: 7.4 Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

storage-buffer

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搭配使用产品

Primary Antibodies

AB308167

Anti-Miz1 antibody [HL1548]

Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Miz1 antibody [HL1548] (AB308167)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIITACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGAEQTEKADA","proteinLength":"Fragment","predictedMolecularWeight":"22.33 kDa","actualMolecularWeight":null,"aminoAcidEnd":188,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q13105","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Lyophilized
运输条件
Blue Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Miz1 also known as Zinc finger Miz1 is a transcription factor with a mass of around 87 kDa. It features multiple zinc finger domains allowing it to bind DNA directly. Miz1 is widely expressed in various tissues particularly in the nucleus of cells. Its function includes both activating and repressing gene transcription depending on the context. By modulating transcription Miz1 plays a critical role in cellular proliferation and differentiation.
Biological function summary

Miz1 interacts with other transcription factors and forms part of larger complexes that influence the expression of genes involved in cell cycle regulation. Frequently Miz1 associates with the Myc protein which modifies its activity allowing for tight control over its function. Through these interactions Miz1 regulates important genes that can tip the balance between cell survival and apoptosis.

Pathways

The function of Miz1 integrates into the TGF-beta and MAPK signaling pathways. In the TGF-beta pathway Miz1 collaborates with Smads to regulate target genes that govern cell growth. Meanwhile in the MAPK pathway Miz1's interaction with Myc influences gene expression impacting cellular responses to external signals. These pathways support Miz1's role in controlling cell proliferation and stress responses.

Miz1 demonstrates significant involvement in cancer and developmental disorders. Dysregulation of Miz1 can lead to uncontrolled cell proliferation contributing to oncogenesis. Miz1's interaction with Myc is particularly linked to its oncogenic potential affecting genes that drive tumor progression. Additionally mutations or alterations in Miz1 function can impact developmental processes suggesting its role in some congenital conditions.
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常规信息

功能

Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed : 25245946).

序列相似性

Belongs to the krueppel C2H2-type zinc-finger protein family.

翻译后修饰

Undergoes 'Lys-48'-linked polyubiquitination at Lys-397 and Lys-481 and subsequent proteasomal degradation in a TRAF2-dependent manner.

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产品实验方案

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靶点信息

Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed : 25245946).
See full target information ZBTB17
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