AB158883

重组人 MFI2/MTf 蛋白 (GST tag N-Terminus)

Name: 重组人MFI2/MTf蛋白 (ab158883)| Abcam中文官网
Brand: Abcam Limited
SKU: AB158883
Price: 6621 CNY
Availability: InStock

Recombinant Human MFI2/MTf protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

(0 Publication)

Recombinant Human MFI2/MTf protein (GST tag N-Terminus) is a Human Full Length protein, in the 21 to 302 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

CD228, MAP97, MFI2, MELTF, Melanotransferrin, Melanoma-associated antigen p97

1 Images

SDS-PAGE - Recombinant Human MFI2/MTf protein (GST tag N-Terminus) (AB158883)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MFI2/MTf protein (GST tag N-Terminus) (AB158883)

ab158883 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

应用

WB, ELISA

applications

生物活性

访问

P08582

不含动物源

不含载体蛋白

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

style

left-column

产品详情

This product was previously labelled as MFI2.

style

left-column

序列信息

[{"sequence":"MEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSADHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVTIDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDHFGGSCVPGAGETSYSESLCRLCRGDSPGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDESPSRRQTWTRSEEEEGECPAHEEARRTMRSSAGQAWKWAPVHRPQDESDKGEFGKRAKSRDMLG","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":302,"aminoAcidStart":21,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P08582","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

style

left-column

性能和储存信息

运输条件

Dry Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

False

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MFI2/MTf also known as melanotransferrin or p97 is a membrane-associated glycoprotein with a mass of approximately 70 kDa. This target is expressed in various tissues including marmoset breast tissue and is notably abundant in the brain and skin. MFI2/MTf exhibits a pivotal role at the cell surface where it interacts with transferrin receptors and heparan sulfate proteoglycans. Although associated with iron metabolism it does not bind iron directly but plays a part in the cellular uptake of iron.

Biological function summary

MFI2/MTf participates in cellular processes related to growth and development. It is involved in promoting cell proliferation and migration and its expression is upregulated in several cancers indicating a possible role in tumor growth. MFI2/MTf does not form a part of a larger known complex but interacts with other molecules at the cell surface that influence its activity. Researchers consider it an important marker for both physiological growth and pathological conditions like malignancies.

Pathways

MFI2/MTf functions as an important player in the iron homeostasis and MAPK signaling pathways. It interacts with proteins such as the transferrin receptor and various growth factor receptors. These interactions contribute to pathways governing cellular proliferation and survival. Its engagement in these pathways suggests that MFI2/MTf is important for maintaining cellular functions that rely on iron metabolism and signal transduction which are critical in both normal and disease states.

MFI2/MTf has associations with melanoma and neurodegenerative conditions such as Alzheimer's disease. In melanoma it integrates into mechanisms involving other proteins like metalloproteinases enhancing invasive capabilities. In neurodegenerative contexts an aberrant expression or altered function of MFI2/MTf might contribute to pathological processes potentially involving interactions with amyloid precursor proteins. These connections highlight the significance of MFI2/MTf in understanding and possibly targeting these disorders.

style

left-column

特殊说明

形式

Liquid

style

left-column

常规信息

功能

Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

序列相似性

Belongs to the transferrin family.

style

left-column

产品实验方案

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

See full target information MELTF

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组人 MFI2/MTf 蛋白 (GST tag N-Terminus)

Recombinant Human MFI2/MTf protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human MFI2/MTf protein (GST tag N-Terminus) (AB158883)

关键信息

表达系统

标签

应用

生物活性

访问

不含动物源

不含载体蛋白

种属

存储溶液