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AB153226

重组人MED13L蛋白

Recombinant Human MED13L protein

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Recombinant Human MED13L protein is a Human Fragment protein, in the 1186 to 1285 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

KIAA1025, PROSIT240, THRAP2, TRAP240L, MED13L, Mediator of RNA polymerase II transcription subunit 13-like, Mediator complex subunit 13-like, Thyroid hormone receptor-associated protein 2, Thyroid hormone receptor-associated protein complex 240 kDa component-like

1 Images
SDS-PAGE - Recombinant Human MED13L protein (AB153226)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MED13L protein (AB153226)

ab153226 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, ELISA

applications

生物活性

No

访问

Q71F56

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"IFGKNSDIGQAAERRLMMCQSTFLPQVEGTKKPQEPPISLLLLLQNQHTQPFASLNFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQY","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":1285,"aminoAcidStart":1186,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q71F56","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MED13L also known as Mediator Complex Subunit 13-Like is a protein with a molecular mass of approximately 263 kDa. This protein plays a role mechanically as a component of the Mediator complex which is a multiprotein complex that acts as a transcriptional coactivator in eukaryotic cells. MED13L is expressed in various tissues but its expression levels are notably higher in the brain. This indicates its importance in processes related to neural development and function.
Biological function summary

The MED13L protein is integral to the regulation of gene transcription. It functions within the larger context of the Mediator complex which serves as a bridge linking gene-specific transcription factors to the RNA polymerase II enzyme. By modulating the interaction between these transcription factors and polymerase MED13L helps control the expression of target genes. This regulation is important for the proper development and maintenance of many cellular processes particularly in nervous tissues.

Pathways

MED13L is involved in significant biological processes such as cell differentiation and growth. It participates in the Wnt signaling pathway which plays a critical role in embryonic development and cancer pathogenesis. Within this pathway MED13L interacts with other proteins like β-catenin to promote transcriptional activation necessary for cell growth and differentiation. Additionally its role links it to the regulation of the Hedgehog signaling pathway another essential pathway for developmental processes.

Mutations or dysregulation of MED13L have been associated with neurodevelopmental disorders including MED13L haploinsufficiency syndrome which is characterized by intellectual disability and cardiac anomalies. The protein's dysfunction is also linked to certain types of congenital heart defects. In some cases abnormalities in MED13L may interact with components of the Mediator complex affecting the regulation pathways and subsequently contributing to these disorders.
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特殊说明

形式

Liquid

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常规信息

功能

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.

序列相似性

Belongs to the Mediator complex subunit 13 family.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
See full target information MED13L
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Complementary Products

Primary Antibodies

AB87831

Anti-MED13L antibody

Immunoprecipitation - Anti-MED13L antibody (AB87831)

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