重组人MALT1/MLT蛋白(Active) (ab271604)
Key features and details
- Expression system: HEK 293 cells
- Purity: >= 90% SDS-PAGE
- Active: Yes
- Tags: DDDDK tag N-Terminus
- Suitable for: Functional Studies, SDS-PAGE
描述
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产品名称
重组人MALT1/MLT蛋白(Active)
参阅全部 MALT1/MLT 蛋白酶 -
生物活性
Specific Activity: 40 pmol/min/µg. -
纯度
>= 90 % SDS-PAGE. -
表达系统
HEK 293 cells -
Accession
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蛋白长度
Full length protein -
无动物成分
No -
性质
Recombinant -
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种属
Human -
序列
ASGRARCTRK LRNWVVEQVE SGQFPGVCWD DTAKTMFRIP WKHAGKQDFR EDQDAAFFKA WAIFKGKYKE GDTGGPAVWK TRLRCALNKS SEFKEVPERG RMDVAEPYKV YQLLPPGIVS GQPGTQKVPS KRQHSSVSSE RKEEEDAMQN CTLSPSVLQD SLNNEEEGAS GGAVHSDIGS SSSSSSPEPQ EVTDTTEAPF QGDQRSLEFL LPPEPDYSLL LTFIYNGRVV GEAQVQSLDC RLVAEPSGSE SSMEQVLFPK PGPLEPTQRL LSQLERGILV ASNPRGLFVQ RLCPIPISWN APQAPPGPGP HLLPSNECVE LFRTAYFCRD LVRYFQGLGP PPKFQVTLNF WEESHGSSHT PQNLITVKME QAFARYLLEQ TPEQQAAILS LV -
预测分子量
93 kDa including tags -
氨基酸
2 to 824 -
标签
DDDDK tag N-Terminus -
额外的序列信息
80 μg/ml tag peptide
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技术指标
Our Abpromise guarantee covers the use of ab271604 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
Functional Studies
SDS-PAGE
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形式
Liquid -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 0.63% Tris HCl, 0.64% Sodium chloride, 0.02% Potassium chloride, 20% Glycerol (glycerin, glycerine)
100µg/ml DDDDK peptideThis product is an active protein and may elicit a biological response in vivo, handle with caution.
常规信息
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别名
- Caspase like protein
- DKFZp434L132
- IMD12
see all -
功能
Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. -
组织特异性
Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. -
疾病相关
Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. -
序列相似性
Belongs to the peptidase C14B family.
Contains 1 death domain.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. -
细胞定位
Cytoplasm > perinuclear region. Nucleus. Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10. - Information by UniProt
图片
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Functional Studies - Recombinant human MALT1/MLT protein (Active) (ab271604)Specific activity of ab271604.
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SDS-PAGE - Recombinant human MALT1/MLT protein (Active) (ab271604)SDS-PAGE analysis of 2 µg ab271604.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab271604 被引用在 1 文献中.
- Zhang S et al. Inhibition of MALT1 Alleviates Spinal Ischemia/Reperfusion Injury-Induced Neuroinflammation by Modulating Glial Endoplasmic Reticulum Stress in Rats. J Inflamm Res 14:4329-4345 (2021). PubMed: 34511971