JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB174430

重组人 MAGED1/NRAGE 蛋白 (His tag N-Terminus)

Recombinant Human MAGED1/NRAGE protein (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human MAGED1/NRAGE protein (His tag N-Terminus) is a Human Fragment protein, in the 504 to 760 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

查看别名

NRAGE, PP2250, PRO2292, MAGED1, Melanoma-associated antigen D1, MAGE tumor antigen CCF, MAGE-D1 antigen, Neurotrophin receptor-interacting MAGE homolog

1 Images
SDS-PAGE - Recombinant Human MAGED1/NRAGE protein (His tag N-Terminus) (AB174430)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MAGED1/NRAGE protein (His tag N-Terminus) (AB174430)

15% SDS-PAGE analysis of ab174430 (3 μg).

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q9Y5V3

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column

产品详情

This product was previously labelled as MAGED1
style
left-column

序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSLRPSPNSRASQNPGAAQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGP","proteinLength":"Fragment","predictedMolecularWeight":"31.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":760,"aminoAcidStart":504,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y5V3","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MAGED1 also known as NRAGE is a protein with diverse roles in cellular processes. It is a type of MAGE (Melanoma Antigen Gene) family member and its molecular weight is approximately 88 kDa. You find MAGED1 expressed in multiple tissues including the brain and testes where it plays various regulatory roles. This protein associates with other key molecules modulating different signaling events within the cell.
Biological function summary

MAGED1 influences neuronal development by interacting with various cellular components. It acts as a modulator in the NGF (nerve growth factor) and p75 neurotrophin receptor signaling pathways forming a complex with these receptors to manage neuronal apoptosis and differentiation. Its function ensures the appropriate response of neurons to growth signals closely monitoring neuronal growth and survival.

Pathways

MAGED1 is involved in the regulation of apoptosis and neuronal growth signaling. In the apoptosis pathway it partners with p75NTR enhancing the pathway’s pro-apoptotic signals. In neuronal growth signaling it interacts with TrkA and other neurotrophin receptors facilitating the accurate transmission of growth signals. Through these interactions MAGED1 plays a balancing act between promoting cell survival and inducing apoptosis depending on cellular context.

Researchers link MAGED1 to neurodegenerative conditions and cancer. Its involvement in apoptosis and neuronal regulation associates it with Alzheimer’s disease with alterations in MAGED1 expression impacting neuronal cells. Additionally in cancer the imbalance in MAGED1 regulation contributes to tumorigenesis. Its association with proteins like p75NTR and TrkA highlights its role in disease pathways suggesting it potentially serves as a therapeutic target.
style
left-column

特殊说明

形式

Liquid

附加说明

ab174430 is purified by conventional chromatography.

style
left-column

常规信息

功能

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3 : substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed.

亚细胞定位

Nucleus

style
left-column

产品实验方案

style
left-column

靶点信息

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3 : substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed.
See full target information MAGED1
style
left-column
style
left-column
style
right-column

搭配使用产品

Proteins & Peptides

AB174429

Recombinant Human PRPSAP2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human PRPSAP2 protein (His tag N-Terminus) (AB174429)

  • 0
  • 0
Proteins & Peptides

AB174554

Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus) (AB174554)

  • 0
  • 0
Primary Antibodies

AB104627

Anti-MAGED1/NRAGE antibody

Western blot - Anti-MAGED1/NRAGE antibody (AB104627)

  • 0
  • 0
Proteins & Peptides

AB174453

Recombinant Human p50 dynamitin protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human p50 dynamitin protein (His tag N-Terminus) (AB174453)

  • 0
  • 0

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com