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AB167902

重组人MAEA蛋白(denatured)

Recombinant Human MAEA protein (denatured)

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Recombinant Human MAEA protein (denatured) is a Human Full Length protein, in the 1 to 396 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

查看别名

EMP, HLC10, PIG5, MAEA, E3 ubiquitin-protein transferase MAEA, Cell proliferation-inducing gene 5 protein, Erythroblast macrophage protein, Human lung cancer oncogene 10 protein, Macrophage erythroblast attacher, P44EMLP, HLC-10

1 Images
SDS-PAGE - Recombinant Human MAEA protein (denatured) (AB167902)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MAEA protein (denatured) (AB167902)

15% SDS-PAGE analysis of 3µg ab167902.

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q7L5Y9

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 6.01% Urea, 0.32% Tris HCl

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAVQESAAQLSMTLKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSGCPAVDSVVSLLDGVVEKLSVLKRKAVESIQAEDESAKLCKRRIEHLKEHSSDQPAAASVWKRKRMDRMMVEHLLRCGYYNTAVKLARQSGIEDLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFSLRIQEFIELIRQNKRLDAVRHARKHFSQAEGSQLDEVRQAMGMLAFPPDTHISPYKDLLDPARWRMLIQQFRYDNYRLHQLGNNSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPVCSRSLNKLAQPLPMAHCANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDDKVVCPRTKEVFHFSQAEKVYIM","proteinLength":"Full Length","predictedMolecularWeight":"47.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":396,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q7L5Y9","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MAEA also known as Macrophage Erythroblast Attacher is a protein with a mass of approximately 42 kDa. This protein functions mechanically by anchoring mature erythroblasts to macrophages in the erythroblastic islands of the bone marrow. You can find MAEA expression in hematopoietic organs such as the spleen bone marrow and lymph nodes. Its expression is not limited to these sites since several tissues exhibit lower levels of expression indicating a broader biological role.
Biological function summary

MAEA plays a significant role in hematopoiesis by facilitating communication between macrophages and erythroblasts. It forms part of a protein complex that ensures the stability and viability of developing erythrocytes. This protein interaction is critical for the normal maturation of red blood cells helping to maintain the balance and production of these cells under varying physiological conditions.

Pathways

MAEA participates in the erythrophagocytosis and erythroblast enucleation processes. MAEA contributes to the interaction with proteins such as ICAM-4 and VLA-4 which are important in these pathways. Through these interactions MAEA is instrumental in effectively mediating red blood cell clearance and differentiation ensuring the proper function of erythroblastic islands within the bone marrow niche.

MAEA links to pathologies such as anemia and myeloproliferative disorders. Altered MAEA expression or function can disturb normal erythropoiesis leading to ineffective red blood cell production and anemia. Additionally its interaction with proteins like ICAM-4 can affect disease progression and severity. Researchers continue to study these connections to understand MAEA’s role in hematological disorders better.
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特殊说明

形式

Liquid

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常规信息

功能

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed : 29911972). MAEA is required for normal cell proliferation (PubMed : 29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed : 29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed : 9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable).

翻译后修饰

Autoubiquitinated as component of the CTLH E3 ubiquitin-protein ligase complex (in vitro).

亚细胞定位

Nucleus

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed : 29911972). MAEA is required for normal cell proliferation (PubMed : 29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed : 29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed : 9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable).
See full target information MAEA
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