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AB162604

重组人LSR蛋白

Recombinant Human LSR protein

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(0 Publication)

Recombinant Human LSR protein is a Human Full Length protein, in the 1 to 649 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

ILDR3, LISCH, LSR, Lipolysis-stimulated lipoprotein receptor, Angulin-1

1 Images
SDS-PAGE - Recombinant Human LSR protein (AB162604)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human LSR protein (AB162604)

ab162604 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

ELISA, WB

applications

生物活性

No

访问

Q86X29

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MQQDGLGVGTRNGSGKGRSVHPSWPWCAPRPLRYFGRDARARRAQTAAMALLAGGLSRGLGSHPAAAGRDAVVFVWLLLSTWCTAPARAIQVTVSNPYHVVILFQPVTLPCTYQMTSTPTQPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFDQTAWGDSGVYYCSVVSAQDLQGNNEAYAELIVLGRTSGVAELLPGFQAGPIEDWLFVVVVCLAAFLIFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSTYAHLSPAKTPPPPAMIPMGPAYNGYPGGYPGDVDRSSSAGGQGSYVPLLRDTDSSVASEVRSGYRIQASQQDDSMRVLYYMEKELANFDPSRPGPPSGRVERAMSEVTSLHEDDWRSRPSRGPALTPIRDEEWGGHSPRSPRGWDQEPAREQAGGGWRARRPRARSVDALDDLTPPSTAESGSRSPTSNGGRSRAYMPPRSRSRDDLYDQDDSRDFPRSRDPHYDDFRSRERPPADPRSHHHRTRDPRDNGSRSGDLPYDGRLLEEAVRKKGSEERRRPHKEEEEEAYYPPAPPPYSETDSQASRERRLKKNLALSRESLVV","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":649,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q86X29","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The LSR protein also known as Lipolysis Stimulated Lipoprotein Receptor functions mechanically as a component of the plasma membrane where it assists in lipid metabolism. It has a mass of approximately 68 kDa and plays an important role in endocytosis and binding of apolipoproteins. LSR is expressed significantly in liver and intestinal tissues. Researchers often study it for its involvement in lipid management in the human body.
Biological function summary

LSR interacts with other proteins to form a multimeric complex that regulates lipid processing. Its presence is essential for maintaining lipid homeostasis by binding chylomicrons and cholesterol-rich lipoproteins. The LSR complex plays a significant role in managing body lipid levels and maintaining cellular health. These processes contribute to the efficient transport and clearance of dietary fats which are essential functions in metabolic regulation.

Pathways

The activity of the LSR protein is integral to the lipid metabolism and cholesterol homeostasis pathways. Within these pathways LSR collaborates with proteins like APOB and APOE to facilitate lipid uptake and processing. It functions by enabling the clearance of chylomicron remnants and very low-density lipoprotein particles from the bloodstream maintaining lipid balance and preventing disorders related to lipid accumulation.

The dysfunction or altered expression of LSR can associate with hyperlipidemia and atherosclerosis. These conditions result from impaired lipid uptake and clearance leading to elevated blood lipid levels. LSR's interaction with apolipoproteins such as APOB links its activities to the metabolic disturbances observed in these diseases. Understanding LSR's role in lipid mechanisms provides potential avenues for therapeutic interventions targeting lipid-related disorders.
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特殊说明

形式

Liquid

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常规信息

功能

Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity).

序列相似性

Belongs to the immunoglobulin superfamily. LISCH7 family.

翻译后修饰

Phosphorylation at Ser-365 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity).
See full target information LSR
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